Eph-ephrin signaling in nervous system development

Ephrins and Eph receptors enable contact-mediated interactions between cells at every stage of nervous system development. In spite of their broad binding affinities, Eph proteins facilitate specificity in neuronal migration and axon targeting. This review focuses on recent studies that demonstrate...

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Detalles Bibliográficos
Autores principales: Cramer, Karina S., Miko, Ilona J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821289/
https://www.ncbi.nlm.nih.gov/pubmed/27092247
http://dx.doi.org/10.12688/f1000research.7417.1
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author Cramer, Karina S.
Miko, Ilona J.
author_facet Cramer, Karina S.
Miko, Ilona J.
author_sort Cramer, Karina S.
collection PubMed
description Ephrins and Eph receptors enable contact-mediated interactions between cells at every stage of nervous system development. In spite of their broad binding affinities, Eph proteins facilitate specificity in neuronal migration and axon targeting. This review focuses on recent studies that demonstrate how these proteins interact with each other, and with other signaling pathways, to guide specificity in a diverse set of developmental processes.
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spelling pubmed-48212892016-04-17 Eph-ephrin signaling in nervous system development Cramer, Karina S. Miko, Ilona J. F1000Res Review Ephrins and Eph receptors enable contact-mediated interactions between cells at every stage of nervous system development. In spite of their broad binding affinities, Eph proteins facilitate specificity in neuronal migration and axon targeting. This review focuses on recent studies that demonstrate how these proteins interact with each other, and with other signaling pathways, to guide specificity in a diverse set of developmental processes. F1000Research 2016-03-30 /pmc/articles/PMC4821289/ /pubmed/27092247 http://dx.doi.org/10.12688/f1000research.7417.1 Text en Copyright: © 2016 Cramer KS and Miko IJ http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Cramer, Karina S.
Miko, Ilona J.
Eph-ephrin signaling in nervous system development
title Eph-ephrin signaling in nervous system development
title_full Eph-ephrin signaling in nervous system development
title_fullStr Eph-ephrin signaling in nervous system development
title_full_unstemmed Eph-ephrin signaling in nervous system development
title_short Eph-ephrin signaling in nervous system development
title_sort eph-ephrin signaling in nervous system development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821289/
https://www.ncbi.nlm.nih.gov/pubmed/27092247
http://dx.doi.org/10.12688/f1000research.7417.1
work_keys_str_mv AT cramerkarinas ephephrinsignalinginnervoussystemdevelopment
AT mikoilonaj ephephrinsignalinginnervoussystemdevelopment

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