Adaptive response to l‐serine deficiency is mediated by p38 MAPK activation via 1‐deoxysphinganine in normal fibroblasts

Reduced availability of l‐serine limits cell proliferation and leads to an adaptation to l‐serine‐deficient environment, the underlying molecular mechanism of which remain largely unexplored. Genetic ablation of 3‐phosphoglycerate dehydrogenase (Phgdh), which catalyzes the first step of de novo l‐se...

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Detalles Bibliográficos
Autores principales: Sayano, Tomoko, Kawano, Yuki, Kusada, Wataru, Arimoto, Yashiho, Esaki, Kayoko, Hamano, Momoko, Udono, Miyako, Katakura, Yoshinori, Ogawa, Takuya, Kato, Hisanori, Hirabayashi, Yoshio, Furuya, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821351/
https://www.ncbi.nlm.nih.gov/pubmed/27239443
http://dx.doi.org/10.1002/2211-5463.12038

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