A targeted DNA substrate mechanism for the inhibition of HIV‐1 integrase by inhibitors with antiretroviral activity

We recently reported that viral DNA could be the primary target of raltegravir (RAL), an efficient anti‐HIV‐1 drug, which acts by inhibiting integrase. To elucidate this mechanism, we conducted a comparative analysis of RAL and TB11, a diketoacid abandoned as an anti‐HIV‐1 drug for its weak efficien...

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Detalles Bibliográficos
Autores principales: Ammar, Farah F., Hobaika, Zeina, Abdel‐Azeim, Safwat, Zargarian, Loussinée, Maroun, Richard G., Fermandjian, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821353/
https://www.ncbi.nlm.nih.gov/pubmed/27239438
http://dx.doi.org/10.1002/2211-5463.12025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821353/
https://www.ncbi.nlm.nih.gov/pubmed/27239438
http://dx.doi.org/10.1002/2211-5463.12025

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