Enteric Neuronal Damage, Intramuscular Denervation and Smooth Muscle Phenotype Changes as Mechanisms of Chagasic Megacolon: Evidence from a Long-Term Murine Model of Tripanosoma cruzi Infection

We developed a novel murine model of long-term infection with Trypanosoma cruzi with the aim to elucidate the pathogenesis of megacolon and the associated adaptive and neuromuscular intestinal disorders. Our intent was to produce a chronic stage of the disease since the early treatment should avoid...

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Detalles Bibliográficos
Autores principales: Campos, Camila França, Cangussú, Silvia Dantas, Duz, Ana Luiza Cassin, Cartelle, Christiane Teixeira, Noviello, Maria de Lourdes, Veloso, Vanja Maria, Bahia, Maria Terezinha, Almeida-Leite, Camila Megale, Arantes, Rosa Maria Esteves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821538/
https://www.ncbi.nlm.nih.gov/pubmed/27045678
http://dx.doi.org/10.1371/journal.pone.0153038

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