Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection

BACKGROUND: The Brugia malayi Bm-103 and Bm-RAL-2 proteins are orthologous to Onchocerca volvulus Ov-103 and Ov-RAL-2, and which were selected as the best candidates for the development of an O. volvulus vaccine. The B. malayi gerbil model was used to confirm the efficacy of these Ov vaccine candida...

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Detalles Bibliográficos
Autores principales: Arumugam, Sridhar, Wei, Junfei, Liu, Zhuyun, Abraham, David, Bell, Aaron, Bottazzi, Maria Elena, Hotez, Peter J., Zhan, Bin, Lustigman, Sara, Klei, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821550/
https://www.ncbi.nlm.nih.gov/pubmed/27045170
http://dx.doi.org/10.1371/journal.pntd.0004586

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