Molecular Dynamics Simulations to Investigate the Influences of Amino Acid Mutations on Protein Three-Dimensional Structures of Cytochrome P450 2D6.1, 2, 10, 14A, 51, and 62

Many natural mutants of the drug metabolizing enzyme cytochrome P450 (CYP) 2D6 have been reported. Because the enzymatic activities of many mutants are different from that of the wild type, the genetic polymorphism of CYP2D6 plays an important role in drug metabolism. In this study, the molecular dy...

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Detalles Bibliográficos
Autores principales: Fukuyoshi, Shuichi, Kometani, Masaharu, Watanabe, Yurie, Hiratsuka, Masahiro, Yamaotsu, Noriyuki, Hirono, Shuichi, Manabe, Noriyoshi, Takahashi, Ohgi, Oda, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821567/
https://www.ncbi.nlm.nih.gov/pubmed/27046024
http://dx.doi.org/10.1371/journal.pone.0152946

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