Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO−cGMP−PKG−K(ATP)Channel Signaling Pathway

In the present study, the effect and mechanism of action of the flavonoid naringenin were evaluated in superoxide anion donor (KO(2))-induced inflammatory pain in mice. Naringenin reduced KO(2)-induced overt-pain like behavior, mechanical hyperalgesia, and thermal hyperalgesia. The analgesic effect...

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Detalles Bibliográficos
Autores principales: Manchope, Marília F., Calixto-Campos, Cássia, Coelho-Silva, Letícia, Zarpelon, Ana C., Pinho-Ribeiro, Felipe A., Georgetti, Sandra R., Baracat, Marcela M., Casagrande, Rúbia, Verri, Waldiceu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821586/
https://www.ncbi.nlm.nih.gov/pubmed/27045367
http://dx.doi.org/10.1371/journal.pone.0153015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821586/
https://www.ncbi.nlm.nih.gov/pubmed/27045367
http://dx.doi.org/10.1371/journal.pone.0153015

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