Cargando…

Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO−cGMP−PKG−K(ATP)Channel Signaling Pathway

In the present study, the effect and mechanism of action of the flavonoid naringenin were evaluated in superoxide anion donor (KO(2))-induced inflammatory pain in mice. Naringenin reduced KO(2)-induced overt-pain like behavior, mechanical hyperalgesia, and thermal hyperalgesia. The analgesic effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manchope, Marília F., Calixto-Campos, Cássia, Coelho-Silva, Letícia, Zarpelon, Ana C., Pinho-Ribeiro, Felipe A., Georgetti, Sandra R., Baracat, Marcela M., Casagrande, Rúbia, Verri, Waldiceu A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821586/ https://www.ncbi.nlm.nih.gov/pubmed/27045367 http://dx.doi.org/10.1371/journal.pone.0153015

Ejemplares similares

Naringenin: an analgesic and anti-inflammatory citrus flavanone
por: Manchope, Marília F., et al.
Publicado: (2016)

Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice
por: Bernardy, Catia C. F., et al.
Publicado: (2017)

The role of cGMP and PKG in cardioprotection
por: Downey, James M, et al.
Publicado: (2009)

The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2
por: Maioli, N.A., et al.
Publicado: (2015)

Role of cGMP/PKG in fat tissue
por: Pfeifer, Alexander
Publicado: (2011)

Structures of human PKG reveal cGMP-selectived activation mechanisms
por: Huang, Gilbert Y, et al.
Publicado: (2013)

Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund's Adjuvant Models of Overt Pain-Like Behavior in Mice
por: Martinez, Renata M., et al.
Publicado: (2016)

Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice
por: Martinez, Renata M., et al.
Publicado: (2016)

cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
por: Park, Min, et al.
Publicado: (2018)

Construction of novel cGMP FRET-sensors based on PKG from Plasmodium falciparum
por: Calamera, Gaia, et al.
Publicado: (2015)

The NO-cGMP-PKG Axis in HFpEF: From Pathological Mechanisms to Potential Therapies
por: Cai, Zhulan, et al.
Publicado: (2023)

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function
por: Gambaryan, Stepan
Publicado: (2022)

Protective Effect of Fermented Soybean Dried Extracts against TPA-Induced Oxidative Stress in Hairless Mice Skin
por: Georgetti, Sandra R., et al.
Publicado: (2013)

PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis
por: Lopes-Pires, M. Elisa, et al.
Publicado: (2015)

The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders
por: Degjoni, Anisa, et al.
Publicado: (2022)

Contribution of Nrf2 Modulation to the Mechanism of Action of Analgesic and Anti-inflammatory Drugs in Pre-clinical and Clinical Stages
por: Staurengo-Ferrari, Larissa, et al.
Publicado: (2019)

Src activation by cGMP/PKG II in osteoblasts: characterization of a mechano-sensitive signalling complex
por: Rangaswami, Hema, et al.
Publicado: (2011)

Protoporphyrin IX Stimulates Melanogenesis, Melanocyte Dendricity, and Melanosome Transport Through the cGMP/PKG Pathway
por: Lv, Jinpeng, et al.
Publicado: (2020)

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development
por: Ferraz, Camila R., et al.
Publicado: (2020)

The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening
por: Calixto-Campos, Cassia, et al.
Publicado: (2013)

Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway
por: Kinoshita, Hideyuki, et al.
Publicado: (2009)

Is enhancing cGMP-PKG signalling a promising therapeutic target for heart failure with preserved ejection fraction?
por: Kovács, Á., et al.
Publicado: (2016)

Nitric Oxide Enhances Keratinocyte Cell Migration by Regulating Rho GTPase via cGMP-PKG Signalling
por: Zhan, Rixing, et al.
Publicado: (2015)

Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway
por: Wen, Jake J., et al.
Publicado: (2020)

Heart Failure With Preserved Ejection Fraction and Obesity: Syndrome of cGMP-PKG Deficiency in Post-Menopausal Women
por: Sinha, Arjun, et al.
Publicado: (2020)

Swimming exercise inhibits myocardial ER stress in the hearts of aged mice by enhancing cGMP-PKG signaling
por: Chang, Pan, et al.
Publicado: (2020)

Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration
por: Roy, Akanksha, et al.
Publicado: (2022)

Role of G-Substrate in the NO/cGMP/PKG Signal Transduction Pathway for Photic Entrainment of the Hamster Circadian Clock
por: Plano, Santiago Andrés, et al.
Publicado: (2021)

Myocardial stretch-induced compliance is abrogated under ischemic conditions and restored by cGMP/PKG-related pathways
por: Leite-Moreira, André M., et al.
Publicado: (2023)

Vinpocetine Reduces Carrageenan-Induced Inflammatory Hyperalgesia in Mice by Inhibiting Oxidative Stress, Cytokine Production and NF-κB Activation in the Paw and Spinal Cord
por: Ruiz-Miyazawa, Kenji W., et al.
Publicado: (2015)

The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain
por: Ding, Yuanyuan, et al.
Publicado: (2017)

cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases
por: VerPlank, Jordan J. S., et al.
Publicado: (2020)

Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α
por: Tawa, Paul, et al.
Publicado: (2022)

Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
por: Lee, Jia Hai, et al.
Publicado: (2007)

cGMP-PKG upregulates PGC1α and improves cardiac function in advanced cardiac hypertrophy independently of RGS2
por: Takimoto, Eiki
Publicado: (2011)

Magnesium Lithospermate B, an Active Extract of Salvia miltiorrhiza, Mediates sGC/cGMP/PKG Translocation in Experimental Vasospasm
por: Chang, Chih-Zen, et al.
Publicado: (2014)

The new nitric oxide donor cyclohexane nitrate induces vasorelaxation, hypotension, and antihypertensive effects via NO/cGMP/PKG pathway
por: Mendes-Júnior, Leônidas das G., et al.
Publicado: (2015)

Sini-San Regulates the NO-cGMP-PKG Pathway in the Spinal Dorsal Horn in a Modified Rat Model of Functional Dyspepsia
por: Wu, Zhenyu, et al.
Publicado: (2020)

Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway
por: Lv, Yajing, et al.
Publicado: (2020)

Nitric Oxide Mobilizes Intracellular Zn(2+) via the GC/cGMP/PKG Signaling Pathway and Stimulates Adipocyte Differentiation
por: Chen, Chien-Wei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dcdhbche2aagm758733cj83cnj