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Combined AKT and MEK Pathway Blockade in Pre-Clinical Models of Enzalutamide-Resistant Prostate Cancer

Despite recent improvements in patient outcomes using newer androgen receptor (AR) pathway inhibitors, treatment resistance in castrate resistant prostate cancer (CRPC) continues to remain a clinical problem. Co-targeting alternate resistance pathways are of significant interest to treat CRPC and de...

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Detalles Bibliográficos
Autores principales:	Toren, Paul, Kim, Soojin, Johnson, Fraser, Zoubeidi, Amina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821639/ https://www.ncbi.nlm.nih.gov/pubmed/27046225 http://dx.doi.org/10.1371/journal.pone.0152861

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