NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells

We examined the role of NFκB1 in the homeostasis and function of peripheral follicular (Fo) B cells. Aging mice lacking NFκB1 (Nfκb1(−/−)) develop lymphoproliferative and multiorgan autoimmune disease attributed in large part to the deregulated activity of Nfκb1(−/−) Fo B cells that produce excessiv...

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Detalles Bibliográficos
Autores principales: de Valle, Elisha, Grigoriadis, George, O’Reilly, Lorraine A., Willis, Simon N., Maxwell, Mhairi J., Corcoran, Lynn M., Tsantikos, Evelyn, Cornish, Jasper K.S., Fairfax, Kirsten A., Vasanthakumar, Ajithkumar, Febbraio, Mark A., Hibbs, Margaret L., Pellegrini, Marc, Banerjee, Ashish, Hodgkin, Philip D., Kallies, Axel, Mackay, Fabienne, Strasser, Andreas, Gerondakis, Steve, Gugasyan, Raffi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821646/
https://www.ncbi.nlm.nih.gov/pubmed/27022143
http://dx.doi.org/10.1084/jem.20151182

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