The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation

IRF8 and IRF1 are transcriptional regulators that play critical roles in the development and function of myeloid cells, including activation of macrophages by proinflammatory signals such as interferon-γ (IFN-γ). Loss of IRF8 or IRF1 function causes severe susceptibility to infections in mice and in...

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Detalles Bibliográficos
Autores principales: Langlais, David, Barreiro, Luis B., Gros, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821649/
https://www.ncbi.nlm.nih.gov/pubmed/27001747
http://dx.doi.org/10.1084/jem.20151764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821649/
https://www.ncbi.nlm.nih.gov/pubmed/27001747
http://dx.doi.org/10.1084/jem.20151764

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