Cargando…
The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation
IRF8 and IRF1 are transcriptional regulators that play critical roles in the development and function of myeloid cells, including activation of macrophages by proinflammatory signals such as interferon-γ (IFN-γ). Loss of IRF8 or IRF1 function causes severe susceptibility to infections in mice and in...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821649/ https://www.ncbi.nlm.nih.gov/pubmed/27001747 http://dx.doi.org/10.1084/jem.20151764 |