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Multi-perspective smFRET reveals rate-determining late intermediates of ribosomal translocation

Directional translocation of the ribosome through the messenger RNA open reading frame is a critical determinant of translational fidelity. This process entails a complex interplay of large-scale conformational changes within the actively translating particle, which together coordinate the movement...

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Detalles Bibliográficos
Autores principales: Wasserman, Michael R., Alejo, Jose L., Altman, Roger B., Blanchard, Scott C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821728/
https://www.ncbi.nlm.nih.gov/pubmed/26926435
http://dx.doi.org/10.1038/nsmb.3177