How drug resistance takes shape

Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.

Detalles Bibliográficos
Autores principales: Jeselsohn, Rinath, Brown, Myles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821798/
https://www.ncbi.nlm.nih.gov/pubmed/27010172
http://dx.doi.org/10.7554/eLife.14973
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author Jeselsohn, Rinath
Brown, Myles
author_facet Jeselsohn, Rinath
Brown, Myles
author_sort Jeselsohn, Rinath
collection PubMed
description Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.
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spelling pubmed-48217982016-04-07 How drug resistance takes shape Jeselsohn, Rinath Brown, Myles eLife Biophysics and Structural Biology Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present. eLife Sciences Publications, Ltd 2016-03-24 /pmc/articles/PMC4821798/ /pubmed/27010172 http://dx.doi.org/10.7554/eLife.14973 Text en © 2016, Jeselsohn et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Biophysics and Structural Biology
Jeselsohn, Rinath
Brown, Myles
How drug resistance takes shape
title How drug resistance takes shape
title_full How drug resistance takes shape
title_fullStr How drug resistance takes shape
title_full_unstemmed How drug resistance takes shape
title_short How drug resistance takes shape
title_sort how drug resistance takes shape
topic Biophysics and Structural Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821798/
https://www.ncbi.nlm.nih.gov/pubmed/27010172
http://dx.doi.org/10.7554/eLife.14973
work_keys_str_mv AT jeselsohnrinath howdrugresistancetakesshape
AT brownmyles howdrugresistancetakesshape

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