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Treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis
BACKGROUND: Data on the success rate of sitafloxacin treatment in acute complicated urinary tract infection and pyelonephritis are limited. OBJECTIVES: To determine the success rate of a new oral fluoroquinolone, sitafloxacin, in acute complicated urinary tract infection and pyelonephritis. METHODS:...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821846/ https://www.ncbi.nlm.nih.gov/pubmed/27069830 http://dx.doi.org/10.1186/s40064-016-2044-5 |
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author | Manosuthi, Weerawat Wiboonchutikul, Surasak |
author_facet | Manosuthi, Weerawat Wiboonchutikul, Surasak |
author_sort | Manosuthi, Weerawat |
collection | PubMed |
description | BACKGROUND: Data on the success rate of sitafloxacin treatment in acute complicated urinary tract infection and pyelonephritis are limited. OBJECTIVES: To determine the success rate of a new oral fluoroquinolone, sitafloxacin, in acute complicated urinary tract infection and pyelonephritis. METHODS: A prospective study of 30 patients who were diagnosed with acute complicated urinary tract infection and pyelonephritis was conducted. Oral sitafloxacin 50 mg twice a day was given for 7 days. All patients were followed up at baseline, day 7, and day 14. RESULTS: The patient sample included 67 % females; the mean ± SD age was 49 ± 13 years. Twenty-one (70 %) patients had acute pyelonephritis and 9 (30 %) had complicated urinary tract infections. Twenty-two patients were positive for uropathogens. The most frequently isolated pathogen was E. coli 11 non-extended spectrum beta-lactamase (ESBL) producing and 5 ESBL-producing strains. Of the 22 isolated uropathogens, 19 (86 %) isolates were sensitive to sitafloxacin. At day 14, 29 of 30 (97 %) were clinically cured and 21 of 22 (95 %) were microbiologically cured. No patients discontinued sitafloxacin due to adverse events. CONCLUSIONS: These results support the use of oral sitafloxacin in complicated urinary tract infections and acute pyelonephritis. However, further larger studies are required to confirm these results. |
format | Online Article Text |
id | pubmed-4821846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-48218462016-04-11 Treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis Manosuthi, Weerawat Wiboonchutikul, Surasak Springerplus Research BACKGROUND: Data on the success rate of sitafloxacin treatment in acute complicated urinary tract infection and pyelonephritis are limited. OBJECTIVES: To determine the success rate of a new oral fluoroquinolone, sitafloxacin, in acute complicated urinary tract infection and pyelonephritis. METHODS: A prospective study of 30 patients who were diagnosed with acute complicated urinary tract infection and pyelonephritis was conducted. Oral sitafloxacin 50 mg twice a day was given for 7 days. All patients were followed up at baseline, day 7, and day 14. RESULTS: The patient sample included 67 % females; the mean ± SD age was 49 ± 13 years. Twenty-one (70 %) patients had acute pyelonephritis and 9 (30 %) had complicated urinary tract infections. Twenty-two patients were positive for uropathogens. The most frequently isolated pathogen was E. coli 11 non-extended spectrum beta-lactamase (ESBL) producing and 5 ESBL-producing strains. Of the 22 isolated uropathogens, 19 (86 %) isolates were sensitive to sitafloxacin. At day 14, 29 of 30 (97 %) were clinically cured and 21 of 22 (95 %) were microbiologically cured. No patients discontinued sitafloxacin due to adverse events. CONCLUSIONS: These results support the use of oral sitafloxacin in complicated urinary tract infections and acute pyelonephritis. However, further larger studies are required to confirm these results. Springer International Publishing 2016-04-05 /pmc/articles/PMC4821846/ /pubmed/27069830 http://dx.doi.org/10.1186/s40064-016-2044-5 Text en © Manosuthi and Wiboonchutikul. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Manosuthi, Weerawat Wiboonchutikul, Surasak Treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis |
title | Treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis |
title_full | Treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis |
title_fullStr | Treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis |
title_full_unstemmed | Treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis |
title_short | Treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis |
title_sort | treatment outcomes of oral sitafloxacin in acute complicated urinary tract infection and pyelonephritis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821846/ https://www.ncbi.nlm.nih.gov/pubmed/27069830 http://dx.doi.org/10.1186/s40064-016-2044-5 |
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