Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes affect human islet function and if blood-based epigenetic biomarkers reflect these changes and associate with future T2D. We analyse DNA methylati...

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Detalles Bibliográficos
Autores principales: Bacos, Karl, Gillberg, Linn, Volkov, Petr, Olsson, Anders H, Hansen, Torben, Pedersen, Oluf, Gjesing, Anette Prior, Eiberg, Hans, Tuomi, Tiinamaija, Almgren, Peter, Groop, Leif, Eliasson, Lena, Vaag, Allan, Dayeh, Tasnim, Ling, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821875/
https://www.ncbi.nlm.nih.gov/pubmed/27029739
http://dx.doi.org/10.1038/ncomms11089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821875/
https://www.ncbi.nlm.nih.gov/pubmed/27029739
http://dx.doi.org/10.1038/ncomms11089

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