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Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
Rational flux design in metabolic engineering approaches remains difficult since important pathway information is frequently not available. Therefore empirical methods are applied that randomly change absolute and relative pathway enzyme levels and subsequently screen for variants with improved perf...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821882/ https://www.ncbi.nlm.nih.gov/pubmed/27029461 http://dx.doi.org/10.1038/ncomms11163 |