Cargando…
Vascular malformations of central nervous system: A series from tertiary care hospital in South India
AIMS AND OBJECTIVES: To describe clinicopathological features of surgically resected vascular malformations (VMs) of central nervous system (CNS). MATERIALS AND METHODS: Histologically diagnosed cases of VMs of CNS during April 2010–April 2014 were included. Demographic data, clinical and radiologic...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821936/ https://www.ncbi.nlm.nih.gov/pubmed/27114659 http://dx.doi.org/10.4103/0976-3147.176196 |
_version_ | 1782425665595768832 |
---|---|
author | Karri, Sudhir Babu Uppin, Megha S. Rajesh, A. Ashish, K. Bhattacharjee, Suchanda Rani, Y. Jyotsna Sahu, B. P. Saradhi, M Vijaya Purohit, A. K. Challa, Sundaram |
author_facet | Karri, Sudhir Babu Uppin, Megha S. Rajesh, A. Ashish, K. Bhattacharjee, Suchanda Rani, Y. Jyotsna Sahu, B. P. Saradhi, M Vijaya Purohit, A. K. Challa, Sundaram |
author_sort | Karri, Sudhir Babu |
collection | PubMed |
description | AIMS AND OBJECTIVES: To describe clinicopathological features of surgically resected vascular malformations (VMs) of central nervous system (CNS). MATERIALS AND METHODS: Histologically diagnosed cases of VMs of CNS during April 2010–April 2014 were included. Demographic data, clinical and radiological features were obtained. Hematoxylin and eosin slides were reviewed along with Verhoeff-Van Gieson (VVG), Masson's trichrome, periodic acid-Schiff, and Perls' stains. Morphologically, cavernomas and arteriovenous malformations (AVMs) were distinguished on the basis of vessel wall features on VVG and intervening glial parenchyma. RESULTS: Fifty cases were diagnosed as VMs of CNS with an age range of 14–62 years. These included 36 cavernomas, 12 AVMs, 2 mixed capillary-cavernous angiomas. Most of the cavernoma patients (15/36) presented with seizures, whereas AVM patients (8/12) had a headache as the dominant symptom. Twenty-nine patients were reliably diagnosed on radiological features. Microscopic evidence of hemorrhage was seen in 24/36 cavernomas and 6/12 AVMs, as opposed to radiologic evidence of 10 and 4, respectively. Reactive gliosis was seen in 16 cavernomas. CONCLUSIONS: Histological features are important for classifying the VMs of CNS as there are no specific clinical and radiological features. Type of VM has a bearing on management, prognosis, and risk of hemorrhage. |
format | Online Article Text |
id | pubmed-4821936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48219362016-04-25 Vascular malformations of central nervous system: A series from tertiary care hospital in South India Karri, Sudhir Babu Uppin, Megha S. Rajesh, A. Ashish, K. Bhattacharjee, Suchanda Rani, Y. Jyotsna Sahu, B. P. Saradhi, M Vijaya Purohit, A. K. Challa, Sundaram J Neurosci Rural Pract Original Article AIMS AND OBJECTIVES: To describe clinicopathological features of surgically resected vascular malformations (VMs) of central nervous system (CNS). MATERIALS AND METHODS: Histologically diagnosed cases of VMs of CNS during April 2010–April 2014 were included. Demographic data, clinical and radiological features were obtained. Hematoxylin and eosin slides were reviewed along with Verhoeff-Van Gieson (VVG), Masson's trichrome, periodic acid-Schiff, and Perls' stains. Morphologically, cavernomas and arteriovenous malformations (AVMs) were distinguished on the basis of vessel wall features on VVG and intervening glial parenchyma. RESULTS: Fifty cases were diagnosed as VMs of CNS with an age range of 14–62 years. These included 36 cavernomas, 12 AVMs, 2 mixed capillary-cavernous angiomas. Most of the cavernoma patients (15/36) presented with seizures, whereas AVM patients (8/12) had a headache as the dominant symptom. Twenty-nine patients were reliably diagnosed on radiological features. Microscopic evidence of hemorrhage was seen in 24/36 cavernomas and 6/12 AVMs, as opposed to radiologic evidence of 10 and 4, respectively. Reactive gliosis was seen in 16 cavernomas. CONCLUSIONS: Histological features are important for classifying the VMs of CNS as there are no specific clinical and radiological features. Type of VM has a bearing on management, prognosis, and risk of hemorrhage. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4821936/ /pubmed/27114659 http://dx.doi.org/10.4103/0976-3147.176196 Text en Copyright: © Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Karri, Sudhir Babu Uppin, Megha S. Rajesh, A. Ashish, K. Bhattacharjee, Suchanda Rani, Y. Jyotsna Sahu, B. P. Saradhi, M Vijaya Purohit, A. K. Challa, Sundaram Vascular malformations of central nervous system: A series from tertiary care hospital in South India |
title | Vascular malformations of central nervous system: A series from tertiary care hospital in South India |
title_full | Vascular malformations of central nervous system: A series from tertiary care hospital in South India |
title_fullStr | Vascular malformations of central nervous system: A series from tertiary care hospital in South India |
title_full_unstemmed | Vascular malformations of central nervous system: A series from tertiary care hospital in South India |
title_short | Vascular malformations of central nervous system: A series from tertiary care hospital in South India |
title_sort | vascular malformations of central nervous system: a series from tertiary care hospital in south india |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821936/ https://www.ncbi.nlm.nih.gov/pubmed/27114659 http://dx.doi.org/10.4103/0976-3147.176196 |
work_keys_str_mv | AT karrisudhirbabu vascularmalformationsofcentralnervoussystemaseriesfromtertiarycarehospitalinsouthindia AT uppinmeghas vascularmalformationsofcentralnervoussystemaseriesfromtertiarycarehospitalinsouthindia AT rajesha vascularmalformationsofcentralnervoussystemaseriesfromtertiarycarehospitalinsouthindia AT ashishk vascularmalformationsofcentralnervoussystemaseriesfromtertiarycarehospitalinsouthindia AT bhattacharjeesuchanda vascularmalformationsofcentralnervoussystemaseriesfromtertiarycarehospitalinsouthindia AT raniyjyotsna vascularmalformationsofcentralnervoussystemaseriesfromtertiarycarehospitalinsouthindia AT sahubp vascularmalformationsofcentralnervoussystemaseriesfromtertiarycarehospitalinsouthindia AT saradhimvijaya vascularmalformationsofcentralnervoussystemaseriesfromtertiarycarehospitalinsouthindia AT purohitak vascularmalformationsofcentralnervoussystemaseriesfromtertiarycarehospitalinsouthindia AT challasundaram vascularmalformationsofcentralnervoussystemaseriesfromtertiarycarehospitalinsouthindia |