Cargando…
An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials
A nude mouse received subcutaneous injection of human ovarian cancer cells HO-8910PM to form a tumor, and then the tumor fragment was surgically transplanted to the ovary of a recipient mouse to establish an orthotopic cancer model. Tumors occurred in 100% of animals. A mouse displayed an ovarian ma...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821970/ https://www.ncbi.nlm.nih.gov/pubmed/27110559 http://dx.doi.org/10.1155/2016/2585787 |
_version_ | 1782425675835113472 |
---|---|
author | Zhang, Ying Luo, Li Zheng, Xueling Yu, Tinghe |
author_facet | Zhang, Ying Luo, Li Zheng, Xueling Yu, Tinghe |
author_sort | Zhang, Ying |
collection | PubMed |
description | A nude mouse received subcutaneous injection of human ovarian cancer cells HO-8910PM to form a tumor, and then the tumor fragment was surgically transplanted to the ovary of a recipient mouse to establish an orthotopic cancer model. Tumors occurred in 100% of animals. A mouse displayed an ovarian mass, ascites, intraperitoneal spread, and lung metastasis at natural death. The mean survival time was 34.1 ± 17.2 days, with median survival time of 28.5 days. The findings indicated that the present mouse model can reflect the biological behavior of advanced human ovarian cancers. This in vivo model can be used to explore therapeutic means against chemoresistance and metastasis, and an effective treatment would prolong the survival time. |
format | Online Article Text |
id | pubmed-4821970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48219702016-04-24 An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials Zhang, Ying Luo, Li Zheng, Xueling Yu, Tinghe Biomed Res Int Research Article A nude mouse received subcutaneous injection of human ovarian cancer cells HO-8910PM to form a tumor, and then the tumor fragment was surgically transplanted to the ovary of a recipient mouse to establish an orthotopic cancer model. Tumors occurred in 100% of animals. A mouse displayed an ovarian mass, ascites, intraperitoneal spread, and lung metastasis at natural death. The mean survival time was 34.1 ± 17.2 days, with median survival time of 28.5 days. The findings indicated that the present mouse model can reflect the biological behavior of advanced human ovarian cancers. This in vivo model can be used to explore therapeutic means against chemoresistance and metastasis, and an effective treatment would prolong the survival time. Hindawi Publishing Corporation 2016 2016-03-23 /pmc/articles/PMC4821970/ /pubmed/27110559 http://dx.doi.org/10.1155/2016/2585787 Text en Copyright © 2016 Ying Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Ying Luo, Li Zheng, Xueling Yu, Tinghe An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials |
title | An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials |
title_full | An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials |
title_fullStr | An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials |
title_full_unstemmed | An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials |
title_short | An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials |
title_sort | advanced orthotopic ovarian cancer model in mice for therapeutic trials |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821970/ https://www.ncbi.nlm.nih.gov/pubmed/27110559 http://dx.doi.org/10.1155/2016/2585787 |
work_keys_str_mv | AT zhangying anadvancedorthotopicovariancancermodelinmicefortherapeutictrials AT luoli anadvancedorthotopicovariancancermodelinmicefortherapeutictrials AT zhengxueling anadvancedorthotopicovariancancermodelinmicefortherapeutictrials AT yutinghe anadvancedorthotopicovariancancermodelinmicefortherapeutictrials AT zhangying advancedorthotopicovariancancermodelinmicefortherapeutictrials AT luoli advancedorthotopicovariancancermodelinmicefortherapeutictrials AT zhengxueling advancedorthotopicovariancancermodelinmicefortherapeutictrials AT yutinghe advancedorthotopicovariancancermodelinmicefortherapeutictrials |