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Repression of GSK3 restores NK cell cytotoxicity in AML patients

Natural killer cells from acute myeloid leukaemia patients (AML-NK) show a dramatic impairment in cytotoxic activity. The exact reasons for this dysfunction are not fully understood. Here we show that the glycogen synthase kinase beta (GSK3β) expression is elevated in AML-NK cells. Interestingly, GS...

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Detalles Bibliográficos
Autores principales:	Parameswaran, Reshmi, Ramakrishnan, Parameswaran, Moreton, Stephen A., Xia, Zhiqiang, Hou, Yongchun, Lee, Dean A., Gupta, Kalpana, deLima, Marcos, Beck, Rose C., Wald, David N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822012/ https://www.ncbi.nlm.nih.gov/pubmed/27040177 http://dx.doi.org/10.1038/ncomms11154

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