Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

How chemotherapy affects carcinoma genomes is largely unknown. Here we report whole-exome and deep sequencing of 30 paired oesophageal adenocarcinomas sampled before and after neo-adjuvant chemotherapy. Most, but not all, good responders pass through genetic bottlenecks, a feature associated with hi...

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Detalles Bibliográficos
Autores principales: Findlay, John M., Castro-Giner, Francesc, Makino, Seiko, Rayner, Emily, Kartsonaki, Christiana, Cross, William, Kovac, Michal, Ulahannan, Danny, Palles, Claire, Gillies, Richard S., MacGregor, Thomas P., Church, David, Maynard, Nicholas D., Buffa, Francesca, Cazier, Jean-Baptiste, Graham, Trevor A., Wang, Lai-Mun, Sharma, Ricky A., Middleton, Mark, Tomlinson, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822033/
https://www.ncbi.nlm.nih.gov/pubmed/27045317
http://dx.doi.org/10.1038/ncomms11111

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