A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer

A deeper mechanistic understanding of tumour angiogenesis regulation is needed to improve current anti-angiogenic therapies. Here we present evidence from systems-based miRNA analyses of large-scale patient data sets along with in vitro and in vivo experiments that miR-192 is a key regulator of angi...

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Detalles Bibliográficos
Autores principales: Wu, Sherry Y., Rupaimoole, Rajesha, Shen, Fangrong, Pradeep, Sunila, Pecot, Chad V., Ivan, Cristina, Nagaraja, Archana S., Gharpure, Kshipra M., Pham, Elizabeth, Hatakeyama, Hiroto, McGuire, Michael H., Haemmerle, Monika, Vidal-Anaya, Viviana, Olsen, Courtney, Rodriguez-Aguayo, Cristian, Filant, Justyna, Ehsanipour, Ehsan A., Herbrich, Shelley M., Maiti, Sourindra N., Huang, Li, Kim, Ji Hoon, Zhang, Xinna, Han, Hee-Dong, Armaiz-Pena, Guillermo N., Seviour, Elena G., Tucker, Sue, Zhang, Min, Yang, Da, Cooper, Laurence J. N., Ali-Fehmi, Rouba, Bar-Eli, Menashe, Lee, Ju-Seog, Ram, Prahlad T., Baggerly, Keith A., Lopez-Berestein, Gabriel, Hung, Mien-Chie, Sood, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822037/
https://www.ncbi.nlm.nih.gov/pubmed/27041221
http://dx.doi.org/10.1038/ncomms11169

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