Connexins and pannexins in liver damage

Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxic...

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Detalles Bibliográficos
Autores principales: Crespo Yanguas, Sara, Willebrords, Joost, Maes, Michaël, da Silva, Tereza Cristina, Veloso Alves Pereira, Isabel, Cogliati, Bruno, Zaidan Dagli, Maria Lucia, Vinken, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822047/
https://www.ncbi.nlm.nih.gov/pubmed/27065778
http://dx.doi.org/10.17179/excli2016-119
Descripción
Sumario:Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these deleterious events connexins and pannexins could represent a set of novel clinical diagnostic biomarkers and drug targets.

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