Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

Rheumatoid arthritis (RA)-associated IgG antibodies such as anti-citrullinated protein antibodies (ACPAs) have diverse glycosylation variants; however, key sugar chains modulating the arthritogenic activity of IgG remain to be clarified. Here, we show that reduced sialylation is a common feature of...

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Detalles Bibliográficos
Autores principales: Ohmi, Yuhsuke, Ise, Wataru, Harazono, Akira, Takakura, Daisuke, Fukuyama, Hidehiro, Baba, Yoshihiro, Narazaki, Masashi, Shoda, Hirofumi, Takahashi, Nobunori, Ohkawa, Yuki, Ji, Shuting, Sugiyama, Fumihiro, Fujio, Keishi, Kumanogoh, Atsushi, Yamamoto, Kazuhiko, Kawasaki, Nana, Kurosaki, Tomohiro, Takahashi, Yoshimasa, Furukawa, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822049/
https://www.ncbi.nlm.nih.gov/pubmed/27046227
http://dx.doi.org/10.1038/ncomms11205

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