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Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer

PURPOSE: This study was designed to assess the protein levels of transformation/transcription domain-associated protein (TRRAP) in invasive ductal breast carcinomas, and investigated the association between TRRAP and the clinicopathological features of breast cancer. METHODS: We examined TRRAP prote...

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Autores principales: Wang, Ji, Shan, Ming, Liu, Tong, Shi, Qingyu, Zhong, Zhenbin, Wei, Wei, Pang, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Breast Cancer Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822108/
https://www.ncbi.nlm.nih.gov/pubmed/27066097
http://dx.doi.org/10.4048/jbc.2016.19.1.61
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author Wang, Ji
Shan, Ming
Liu, Tong
Shi, Qingyu
Zhong, Zhenbin
Wei, Wei
Pang, Da
author_facet Wang, Ji
Shan, Ming
Liu, Tong
Shi, Qingyu
Zhong, Zhenbin
Wei, Wei
Pang, Da
author_sort Wang, Ji
collection PubMed
description PURPOSE: This study was designed to assess the protein levels of transformation/transcription domain-associated protein (TRRAP) in invasive ductal breast carcinomas, and investigated the association between TRRAP and the clinicopathological features of breast cancer. METHODS: We examined TRRAP protein expression in 470 breast cancer tissues and normal breast tissues by tissue microarray to study the correlation between TRRAP expression and clinicopathological features. This was analyzed using the chi-square test. Kaplan-Meier survival curves and log-rank tests were applied to analyze the survival status. Cox regression was applied for multivariate analysis of prognosis. RESULTS: The data demonstrated that expression of TRRAP was significantly lower in breast carcinomas (36.6%) than in corresponding normal breast tissues (50.8%). In addition, TRRAP protein levels negatively correlated with tumor size, and indicated poor differentiation, increased nodal involvement, and low p53-positive rates. Analysis of survival revealed that lower TRRAP expression correlated with shorter survival time. Univariate analyses identified TRRAP and progesterone receptor as independent protective factors for breast cancer prognosis. However, Ki-67, tumor size, and nodal involvement appeared to be independent risk factors. CONCLUSION: The findings indicate a significant correlation between TRRAP protein levels and adverse prognosis in breast cancer. Therefore, TRRAP could be a prognostic biomarker for breast cancer. In addition, TRRAP is also a predictive biomarker of breast cancer treatment.
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spelling pubmed-48221082016-04-10 Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer Wang, Ji Shan, Ming Liu, Tong Shi, Qingyu Zhong, Zhenbin Wei, Wei Pang, Da J Breast Cancer Original Article PURPOSE: This study was designed to assess the protein levels of transformation/transcription domain-associated protein (TRRAP) in invasive ductal breast carcinomas, and investigated the association between TRRAP and the clinicopathological features of breast cancer. METHODS: We examined TRRAP protein expression in 470 breast cancer tissues and normal breast tissues by tissue microarray to study the correlation between TRRAP expression and clinicopathological features. This was analyzed using the chi-square test. Kaplan-Meier survival curves and log-rank tests were applied to analyze the survival status. Cox regression was applied for multivariate analysis of prognosis. RESULTS: The data demonstrated that expression of TRRAP was significantly lower in breast carcinomas (36.6%) than in corresponding normal breast tissues (50.8%). In addition, TRRAP protein levels negatively correlated with tumor size, and indicated poor differentiation, increased nodal involvement, and low p53-positive rates. Analysis of survival revealed that lower TRRAP expression correlated with shorter survival time. Univariate analyses identified TRRAP and progesterone receptor as independent protective factors for breast cancer prognosis. However, Ki-67, tumor size, and nodal involvement appeared to be independent risk factors. CONCLUSION: The findings indicate a significant correlation between TRRAP protein levels and adverse prognosis in breast cancer. Therefore, TRRAP could be a prognostic biomarker for breast cancer. In addition, TRRAP is also a predictive biomarker of breast cancer treatment. Korean Breast Cancer Society 2016-03 2016-03-25 /pmc/articles/PMC4822108/ /pubmed/27066097 http://dx.doi.org/10.4048/jbc.2016.19.1.61 Text en © 2016 Korean Breast Cancer Society. All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wang, Ji
Shan, Ming
Liu, Tong
Shi, Qingyu
Zhong, Zhenbin
Wei, Wei
Pang, Da
Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer
title Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer
title_full Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer
title_fullStr Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer
title_full_unstemmed Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer
title_short Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer
title_sort analysis of trrap as a potential molecular marker and therapeutic target for breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822108/
https://www.ncbi.nlm.nih.gov/pubmed/27066097
http://dx.doi.org/10.4048/jbc.2016.19.1.61
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