Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes

Proteasome-catalyzed peptide splicing represents an additional catalytic activity of proteasomes contributing to the pool of MHC-class I-presented epitopes. We here biochemically and functionally characterized a new melanoma gp100 derived spliced epitope. We demonstrate that the gp100(mel)(47–52/40–...

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Detalles Bibliográficos
Autores principales: Ebstein, F., Textoris-Taube, K., Keller, C., Golnik, R., Vigneron, N., Van den Eynde, B. J., Schuler-Thurner, B., Schadendorf, D., Lorenz, F. K. M., Uckert, W., Urban, S., Lehmann, A., Albrecht-Koepke, N., Janek, K., Henklein, P., Niewienda, A., Kloetzel, P. M., Mishto, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822137/
https://www.ncbi.nlm.nih.gov/pubmed/27049119
http://dx.doi.org/10.1038/srep24032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822137/
https://www.ncbi.nlm.nih.gov/pubmed/27049119
http://dx.doi.org/10.1038/srep24032

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