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Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress

BACKGROUND: Anomalies in myocardial structure involving myocyte growth, hypertrophy, differentiation, apoptosis, necrosis etc. affects its function and render cardiac tissue more vulnerable to the development of heart failure. Although oxidative stress has a well-established role in cardiac remodeli...

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Detalles Bibliográficos
Autores principales:	Kumar, Radhakrishnan Rajesh, Narasimhan, Madhusudhanan, Shanmugam, Gobinath, Hong, Jennifer, Devarajan, Asokan, Palaniappan, Sethu, Zhang, Jianhua, Halade, Ganesh V., Darley-Usmar, Victor M., Hoidal, John R., Rajasekaran, Namakkal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822244/ https://www.ncbi.nlm.nih.gov/pubmed/27048381 http://dx.doi.org/10.1186/s12967-016-0839-3

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