Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

BACKGROUND & AIMS: Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells characterised by the invariant TCR-chain, Vα7.2-Jα33, and are restricted by MR1, which presents bacterial vitamin B metabolites. They are important for antibacterial immunity at mucosal sites; however, detaile...

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Detalles Bibliográficos
Autores principales: Jeffery, Hannah C., van Wilgenburg, Bonnie, Kurioka, Ayako, Parekh, Krishan, Stirling, Kathryn, Roberts, Sheree, Dutton, Emma E., Hunter, Stuart, Geh, Daniel, Braitch, Manjit K., Rajanayagam, Jeremy, Iqbal, Tariq, Pinkney, Thomas, Brown, Rachel, Withers, David R., Adams, David H., Klenerman, Paul, Oo, Ye H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822535/
https://www.ncbi.nlm.nih.gov/pubmed/26743076
http://dx.doi.org/10.1016/j.jhep.2015.12.017

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