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Production and clinical development of nanoparticles for gene delivery
Gene therapy is a promising strategy for specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been att...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822651/ https://www.ncbi.nlm.nih.gov/pubmed/27088105 http://dx.doi.org/10.1038/mtm.2016.23 |
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author | Chen, Jie Guo, Zhaopei Tian, Huayu Chen, Xuesi |
author_facet | Chen, Jie Guo, Zhaopei Tian, Huayu Chen, Xuesi |
author_sort | Chen, Jie |
collection | PubMed |
description | Gene therapy is a promising strategy for specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been attempted to improve the safety and efficiency of gene-based therapies. Nanoparticles have been proved to be the most promising vehicles for clinical gene therapy due to their tunable size, shape, surface, and biological behaviors. In this review, the clinical development of nanoparticles for gene delivery will be particularly highlighted. Several promising candidates, which are closest to clinical applications, will be briefly reviewed. Then, the recent developments of nanoparticles for clinical gene therapy will be identified and summarized. Finally, the development of nanoparticles for clinical gene delivery in future will be prospected. |
format | Online Article Text |
id | pubmed-4822651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48226512016-04-17 Production and clinical development of nanoparticles for gene delivery Chen, Jie Guo, Zhaopei Tian, Huayu Chen, Xuesi Mol Ther Methods Clin Dev Review Article Gene therapy is a promising strategy for specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been attempted to improve the safety and efficiency of gene-based therapies. Nanoparticles have been proved to be the most promising vehicles for clinical gene therapy due to their tunable size, shape, surface, and biological behaviors. In this review, the clinical development of nanoparticles for gene delivery will be particularly highlighted. Several promising candidates, which are closest to clinical applications, will be briefly reviewed. Then, the recent developments of nanoparticles for clinical gene therapy will be identified and summarized. Finally, the development of nanoparticles for clinical gene delivery in future will be prospected. Nature Publishing Group 2016-04-06 /pmc/articles/PMC4822651/ /pubmed/27088105 http://dx.doi.org/10.1038/mtm.2016.23 Text en Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Review Article Chen, Jie Guo, Zhaopei Tian, Huayu Chen, Xuesi Production and clinical development of nanoparticles for gene delivery |
title | Production and clinical development of nanoparticles for gene delivery |
title_full | Production and clinical development of nanoparticles for gene delivery |
title_fullStr | Production and clinical development of nanoparticles for gene delivery |
title_full_unstemmed | Production and clinical development of nanoparticles for gene delivery |
title_short | Production and clinical development of nanoparticles for gene delivery |
title_sort | production and clinical development of nanoparticles for gene delivery |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822651/ https://www.ncbi.nlm.nih.gov/pubmed/27088105 http://dx.doi.org/10.1038/mtm.2016.23 |
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