Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity

Amyloid formation of the plasma protein transthyretin (TTR) has been linked to familial amyloid polyneuropathy and senile systemic amyloidosis. Binding of ligands within its natural hormone binding site can stabilize the tetrameric structure and impair amyloid formation. We have recently shown that...

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Detalles Bibliográficos
Autores principales: Nilsson, Lina, Larsson, Andreas, Begum, Afshan, Iakovleva, Irina, Carlsson, Marcus, Brännström, Kristoffer, Sauer-Eriksson, A. Elisabeth, Olofsson, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822800/
https://www.ncbi.nlm.nih.gov/pubmed/27050398
http://dx.doi.org/10.1371/journal.pone.0153112

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