Loss of 5-Hydroxymethylcytosine Is an Independent Unfavorable Prognostic Factor for Esophageal Squamous Cell Carcinoma

Ten-eleven translocation (TET) enzymes catalyze the oxidation of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine and 5-carboxylcytosine, which result in genomic DNA demethylation. It was reported that 5-hmC levels were decreased in a variety of cancers and could be regar...

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Detalles Bibliográficos
Autores principales: Shi, Xuejiao, Yu, Yue, Luo, Mei, Zhang, Zhirong, Shi, Susheng, Feng, Xiaoli, Chen, Zhaoli, He, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822830/
https://www.ncbi.nlm.nih.gov/pubmed/27050164
http://dx.doi.org/10.1371/journal.pone.0153100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822830/
https://www.ncbi.nlm.nih.gov/pubmed/27050164
http://dx.doi.org/10.1371/journal.pone.0153100

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