Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model

BACKGROUND: Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacter...

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Detalles Bibliográficos
Autores principales: MacDiarmid, Jennifer A., Langova, Veronika, Bailey, Dale, Pattison, Scott T., Pattison, Stacey L., Christensen, Neil, Armstrong, Luke R., Brahmbhatt, Vatsala N., Smolarczyk, Katarzyna, Harrison, Matthew T., Costa, Marylia, Mugridge, Nancy B., Sedliarou, Ilya, Grimes, Nicholas A., Kiss, Debra L., Stillman, Bruce, Hann, Christine L., Gallia, Gary L., Graham, Robert M., Brahmbhatt, Himanshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822833/
https://www.ncbi.nlm.nih.gov/pubmed/27050167
http://dx.doi.org/10.1371/journal.pone.0151832

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