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LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions

We analyzed the mechanism underlying 5-aminoimidazole-4-carboxamide riboside (AICAR) mediated apoptosis in LKB1-null non-small cell lung cancer (NSCLC) cells. Metabolic profile analysis revealed depletion of the intracellular pyrimidine pool after AICAR treatment, but uridine was the only nucleotide...

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Detalles Bibliográficos
Autores principales:	Liu, Fakeng, Jin, Rui, Liu, Xiuju, Huang, Henry, Wilkinson, Scott C., Zhong, Diansheng, Khuri, Fadlo R., Fu, Haian, Marcus, Adam, He, Yulong, Zhou, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823052/ https://www.ncbi.nlm.nih.gov/pubmed/26506235 http://dx.doi.org/10.18632/oncotarget.6224

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