Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

Statins purportedly exert anti-tumoral effects on breast cancer. However, the biologic mechanisms for these actions are not fully elucidated. The aims of this study were 1) to explore the effects of simvastatin on apoptosis, proliferation as well as PI3K/Akt/mTOR and MAPK/ERK pathway in a window-of-...

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Detalles Bibliográficos
Autores principales: Wang, Tingting, Seah, Serena, Loh, Xinyi, Chan, Ching-Wan, Hartman, Mikael, Goh, Boon-Cher, Lee, Soo-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823053/
https://www.ncbi.nlm.nih.gov/pubmed/26565813
http://dx.doi.org/10.18632/oncotarget.6304

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