Cargando…

pERK/pAkt phenotyping in circulating tumor cells as a biomarker for sorafenib efficacy in patients with advanced hepatocellular carcinoma

Sorafenib is a multikinase inhibitor approved for the treatment of advanced hepatocellular carcinoma (HCC). However, therapeutic response to sorafenib was not equal among HCC patients. Here we present a novel system to provide quantitative information concerning sorafenib-related targets by simultan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jun, Shi, Lehua, Zhang, Xiaofeng, Sun, Bin, Yang, Yefa, Ge, Naijian, Liu, Huiying, Yang, Xia, Chen, Lei, Qian, Haihua, Wu, Mengchao, Yin, Zhengfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823061/ https://www.ncbi.nlm.nih.gov/pubmed/26544731 http://dx.doi.org/10.18632/oncotarget.6104

Ejemplares similares

Loss of Bmp2 impairs odontogenesis via dysregulating pAkt/pErk/GCN5/Dlx3/Sp7
por: Chen, Shuo, et al.
Publicado: (2023)

Detection of Circulating Tumor Cells in Hepatocellular Carcinoma Using Antibodies against Asialoglycoprotein Receptor, Carbamoyl Phosphate Synthetase 1 and Pan-Cytokeratin
por: Li, Jun, et al.
Publicado: (2014)

Imatinib Mesylate Reduces Neurotrophic Factors and pERK and pAKT Expression in Urinary Bladder of Female Mice With Cyclophosphamide-Induced Cystitis
por: Perkins, Megan, et al.
Publicado: (2022)

Increasing AR by HIF-2α inhibitor (PT-2385) overcomes the side-effects of sorafenib by suppressing hepatocellular carcinoma invasion via alteration of pSTAT3, pAKT and pERK signals
por: Xu, Junjie, et al.
Publicado: (2017)

Clinical significance of pAkt and pErk1/2 expression in early-stage breast cancer patients treated with anthracycline-based adjuvant chemotherapy
por: LIU, WENJUAN, et al.
Publicado: (2015)

pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cancer: a translational subgroup analysis from AIO-PK0104
por: Ormanns, Steffen, et al.
Publicado: (2014)

Antiproliferative and Anti-invasion Effects of Carvacrol on PC3 Human Prostate Cancer Cells through Reducing pSTAT3, pAKT, and pERK1/2 Signaling Proteins
por: Heidarian, Esfandiar, et al.
Publicado: (2019)

Predicting the response to sorafenib in hepatocellular carcinoma: where is the evidence for phosphorylated extracellular signaling-regulated kinase (pERK)?
por: Zhu, Andrew X
Publicado: (2009)

Increased expression of pAKT is associated with radiation resistance in cervical cancer
por: Kim, T-J, et al.
Publicado: (2006)

Expression of the Androgen Receptor, pAkt, and pPTEN in Breast Cancer and Their Potential in Prognostication()
por: Sultana, Aisha, et al.
Publicado: (2014)

Modulation of signaling cross-talk between pJNK and pAKT generates optimal apoptotic response
por: Biswas, Sharmila, et al.
Publicado: (2022)

Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT
por: Aboouf, Mostafa A., et al.
Publicado: (2022)

Expression of pAkt affects p53 codon 72 polymorphism-based prediction of response to radiotherapy in nasopharyngeal carcinoma
por: Xie, Xiaoxue, et al.
Publicado: (2013)

Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer
por: Zhou, Ling, et al.
Publicado: (2018)

Identification of pAKT as a pharmacodynamic marker for MER kinase in human melanoma G361 cells
por: Chen, Yaoyu, et al.
Publicado: (2020)

Feasibility and Safety of Delayed Catheter Removal Technique in Percutaneous Trans-Hepatic Portal Vein Embolization
por: He, Chengjian, et al.
Publicado: (2022)

Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway
por: Xu, Fengkai, et al.
Publicado: (2019)

Intratumoral Hepatic Stellate Cells as a Poor Prognostic Marker and a New Treatment Target for Hepatocellular Carcinoma
por: Sun, Bin, et al.
Publicado: (2013)

Progranulin modulates cholangiocarcinoma cell proliferation, apoptosis, and motility via the PI3K/pAkt pathway
por: Daya, Minerva, et al.
Publicado: (2018)

ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics
por: Levidou, Georgia, et al.
Publicado: (2012)

CELLFOOD™ induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways
por: Nuvoli, Barbara, et al.
Publicado: (2014)

Counteracting the activation of pAkt by inhibition of MEK/Erk inhibition reduces actin disruption-mediated apoptosis in PTEN-null PC3M prostate cancer cell lines
por: AHN, YONG-TAE, et al.
Publicado: (2013)

Doxorubicin Induces Cytotoxicity through Upregulation of pERK–Dependent ATF3
por: Park, Eun-Jung, et al.
Publicado: (2012)

Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch
por: Jiang, Guan-Yu, et al.
Publicado: (2015)

A NANOG‐pERK reciprocal regulatory circuit regulates Nanog autoregulation and ERK signaling dynamics
por: Kale, Hanuman T, et al.
Publicado: (2022)

Ras Isoprenylation and pAkt Inhibition by Zoledronic Acid and Fluvastatin Enhances Paclitaxel Activity in T24 Bladder Cancer Cells
por: Li, Shaojuan, et al.
Publicado: (2011)

Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis
por: Jana, Sayantan, et al.
Publicado: (2016)

Correction: CELLFOOD™ induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways
por: Nuvoli, Barbara, et al.
Publicado: (2022)

Intrinsic Aerobic Capacity Affects Hippocampal pAkt and HSP72 Response to an Acute High Fat Diet and Heat Treatment in Rats
por: Gan, Li, et al.
Publicado: (2021)

Sensitization of Cancer Cells through Reduction of Total Akt and Downregulation of Salinomycin-Induced pAkt, pGSk3β, pTSC2, and p4EBP1 by Cotreatment with MK-2206
por: Choi, Ae-Ran, et al.
Publicado: (2014)

Pathobiological Implications of the Expression of EGFR, pAkt, NF-κB and MIC-1 in Prostate Cancer Stem Cells and Their Progenies
por: Mimeault, Murielle, et al.
Publicado: (2012)

Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival
por: Schultz, Chad R, et al.
Publicado: (2012)

Yanghe Huayan decoction inhibits the capability of trans-endothelium and angiogenesis of HER2+ breast cancer via pAkt signaling
por: Liu, Xiao-Fei, et al.
Publicado: (2019)

The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice
por: Peterson, Stephen J., et al.
Publicado: (2009)

Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers
por: Harlé, A, et al.
Publicado: (2015)

Eribulin Synergistically Increases Anti-Tumor Activity of an mTOR Inhibitor by Inhibiting pAKT/pS6K/pS6 in Triple Negative Breast Cancer
por: Wen, Wei, et al.
Publicado: (2019)

Enhancement of Anxiety and Modulation of TH and pERK Expressions in Amygdala by Repeated Injections of Corticosterone
por: Lim, Heena, et al.
Publicado: (2012)

Using pERK immunostaining to quantify neuronal activity induced by stress in zebrafish larvae
por: Corradi, Laura, et al.
Publicado: (2022)

Corrigendum to “Sensitization of Cancer Cells through Reduction of Total Akt and Downregulation of Salinomycin-Induced pAkt, pGSk3β, pTSC2, and p4EBP1 by Cotreatment with MK-2206”
por: Choi, Ae-Ran, et al.
Publicado: (2015)

Midkine promotes hepatocellular carcinoma metastasis by elevating anoikis resistance of circulating tumor cells
por: Sun, Bin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_svgoejg88anf03jgbpu34nu6s4