Combinatorial drug screening and molecular profiling reveal diverse mechanisms of intrinsic and adaptive resistance to BRAF inhibition in V600E BRAF mutant melanomas

Over half of BRAFV600E melanomas display intrinsic resistance to BRAF inhibitors, in part due to adaptive signaling responses. In this communication we ask whether BRAFV600E melanomas share common adaptive responses to BRAF inhibition that can provide clinically relevant targets for drug combination...

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Detalles Bibliográficos
Autores principales: Roller, Devin G., Capaldo, Brian, Bekiranov, Stefan, Mackey, Aaron J., Conaway, Mark R., Petricoin, Emanuel F., Gioeli, Daniel, Weber, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823068/
https://www.ncbi.nlm.nih.gov/pubmed/26673621
http://dx.doi.org/10.18632/oncotarget.6548

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