A novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells

All-trans retinoic acid (ATRA) treatment yields cure rates > 80% through proteasomal degradation of the PML-RARα fusion protein that typically promotes acute promyelocytic leukemia (APL). However, recent evidence indicates that ATRA can also promote differentiation of leukemia cells that are PML-...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Guanhua, Shi, Lulu, Guo, Yuqi, Yu, Linchang, Wang, Lin, Zhang, Xiaoyu, Li, Lianlian, Han, Yang, Ren, Xia, Guo, Qiang, Bi, Kehong, Jiang, Guosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823096/
https://www.ncbi.nlm.nih.gov/pubmed/26673819
http://dx.doi.org/10.18632/oncotarget.6551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823096/
https://www.ncbi.nlm.nih.gov/pubmed/26673819
http://dx.doi.org/10.18632/oncotarget.6551

Ejemplares similares