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A novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells
All-trans retinoic acid (ATRA) treatment yields cure rates > 80% through proteasomal degradation of the PML-RARα fusion protein that typically promotes acute promyelocytic leukemia (APL). However, recent evidence indicates that ATRA can also promote differentiation of leukemia cells that are PML-...
Autores principales: | Song, Guanhua, Shi, Lulu, Guo, Yuqi, Yu, Linchang, Wang, Lin, Zhang, Xiaoyu, Li, Lianlian, Han, Yang, Ren, Xia, Guo, Qiang, Bi, Kehong, Jiang, Guosheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823096/ https://www.ncbi.nlm.nih.gov/pubmed/26673819 http://dx.doi.org/10.18632/oncotarget.6551 |
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