Cargando…

Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma

The BCL6 oncogene plays a crucial role in sustaining diffuse large B-cell lymphomas (DLBCL) through transcriptional repression of key checkpoint genes. BCL6-targeted therapy kills lymphoma cells by releasing these checkpoints. However BCL6 also directly represses several DLBCL oncogenes such as BCL2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dupont, Thibault, Yang, ShaoNing, Patel, Jayeshkumar, Hatzi, Katerina, Malik, Alka, Tam, Wayne, Martin, Peter, Leonard, John, Melnick, Ari, Cerchietti, Leandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823124/ https://www.ncbi.nlm.nih.gov/pubmed/26657288 http://dx.doi.org/10.18632/oncotarget.6513

Ejemplares similares

A purine scaffold Hsp90 inhibitor destabilizes Bcl6 and has specific anti-tumor activity in Bcl6 dependent B-cell lymphomas
por: Cerchietti, Leandro C, et al.
Publicado: (2009)

The transcriptional modulator BCL6 as a molecular target for breast cancer therapy
por: Walker, Sarah R., et al.
Publicado: (2014)

Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated through distinct biochemical mechanisms
por: Huang, Chuanxin, et al.
Publicado: (2013)

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms
por: Hatzi, Katerina, et al.
Publicado: (2015)

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia
por: Hurtz, Christian, et al.
Publicado: (2011)

BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL
por: Xia, Min, et al.
Publicado: (2022)

Histone Demethylase LSD1 is required for Germinal Center formation and BCL6-driven lymphomagenesis
por: Hatzi, Katerina, et al.
Publicado: (2018)

Hit-and-run lymphomagenesis by the Bcl6 oncogene
por: Green, Michael R, et al.
Publicado: (2014)

Wnt status-dependent oncogenic role of BCL9 and BCL9L in hepatocellular carcinoma
por: Huge, Nicole, et al.
Publicado: (2019)

BCL11A Is Oncogenic and Predicts Poor Outcomes in Natural Killer/T-Cell Lymphoma
por: Shi, Hongyun, et al.
Publicado: (2020)

BCL6 is critical for the development of a diverse primary B cell repertoire
por: Duy, Cihangir, et al.
Publicado: (2010)

Significance of Bcl-2 and Bcl-6 immunostaining in B-Non Hodgkin's lymphoma
por: Mahmoud, Hanan Mohamed, et al.
Publicado: (2011)

Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma
por: Adams, Clare M., et al.
Publicado: (2019)

The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy
por: Fabre, Marie-Sophie, et al.
Publicado: (2020)

High-Grade B-Cell Lymphoma (HGBL) with MYC and BCL2 and/or BCL6 Rearrangements Is Predominantly BCL6-Rearranged and BCL6-Expressing in Taiwan
por: Tsai, Cheng-Chih, et al.
Publicado: (2021)

Bcl-x(L) is an oncogenic driver in colorectal cancer
por: Scherr, Anna-Lena, et al.
Publicado: (2016)

DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas
por: Lai, Anne Y., et al.
Publicado: (2010)

Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2(+) diffuse large B-cell lymphomas
por: Shen, Yajie, et al.
Publicado: (2022)

Mito-priming as a method to engineer Bcl-2 addiction
por: Lopez, Jonathan, et al.
Publicado: (2016)

Oncogene addiction: resetting the safety switch?
por: Li, Yulin, et al.
Publicado: (2014)

C-MYC, BCL2 and BCL6 Translocation in B-cell Non-Hodgkin Lymphoma Cases
por: Salam, Dayang Sharyati Datu Abdul, et al.
Publicado: (2020)

TdT Positive Lymphoma with MYC, BCL2 and BCL6 Rearrangements: A Review of Diagnosis and Treatment
por: Singh, Aditi, et al.
Publicado: (2022)

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas
por: Calvo-Vidal, M. Nieves, et al.
Publicado: (2021)

BCL6 enables Ph(+) acute lymphoblastic leukemia cells to survive BCR-ABL1 kinase inhibition
por: Duy, Cihangir, et al.
Publicado: (2011)

Epigenomic evolution in diffuse large B-cell lymphomas
por: Pan, Heng, et al.
Publicado: (2015)

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
por: Cayrol, Florencia, et al.
Publicado: (2017)

Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA
por: Fairchild, Carter K., et al.
Publicado: (2021)

BCL2 oncogene translocation is mediated by a chi-like consensus
Publicado: (1992)

Targeting Bcl-2 stability to sensitize cells harboring oncogenic ras
por: Peng, Bo, et al.
Publicado: (2015)

BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis
por: Louwen, Frank, et al.
Publicado: (2022)

Corrigendum: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
por: Cayrol, Florencia, et al.
Publicado: (2017)

Turning off the BCL-2 switch to prevent intestinal tumorigenesis
por: van der Heijden, Maartje, et al.
Publicado: (2016)

Switch hitter: Bcl11b in T cells and ILC2s
por: Harly, Christelle, et al.
Publicado: (2019)

The epigenetic regulator CTCF modulates BCL6 in lymphoma
por: Batlle-López, Ana, et al.
Publicado: (2015)

Targeting the Bcl-2 Family in B Cell Lymphoma
por: Adams, Clare M., et al.
Publicado: (2019)

Bcl-B: an “unknown” protein of the Bcl-2 family
por: Pervushin, N. V., et al.
Publicado: (2023)

MEF2B mutations lead to deregulated expression of the BCL6 oncogene in Diffuse Large B cell Lymphoma
por: Ying, Carol Y., et al.
Publicado: (2013)

B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral Immunity to Oncogenic Driver in Pediatric Cancers
por: McLachlan, Tabitha, et al.
Publicado: (2022)

Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors
por: Li, Weiping, et al.
Publicado: (2019)

Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma
por: Batmanov, Kirill, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6qjfnhj8pjo8akgiq0tfl4fgsn