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Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors

In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to stressful life events (SLEs). Eight polymorphisms (SNPs) were tested in 94 Schizophreniainpatients and...

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Autores principales: Mandelli, Laura, Toscano, Elena, Porcelli, Stefano, Fabbri, Chiara, Serretti, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823203/
https://www.ncbi.nlm.nih.gov/pubmed/27081388
http://dx.doi.org/10.4306/pi.2016.13.2.247
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author Mandelli, Laura
Toscano, Elena
Porcelli, Stefano
Fabbri, Chiara
Serretti, Alessandro
author_facet Mandelli, Laura
Toscano, Elena
Porcelli, Stefano
Fabbri, Chiara
Serretti, Alessandro
author_sort Mandelli, Laura
collection PubMed
description In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to stressful life events (SLEs). Eight polymorphisms (SNPs) were tested in 94 Schizophreniainpatients and 176 healthy controls. Schizophrenia patients were also evaluated for SLEs in different life periods. None of the SNPs showed association with schizophrenia. Nevertheless, when crossing genetic variants with childhood SLEs, we could observe trends of interaction with age of onset. Though several limitations, our results support a protective role of ST8SIA2 in individuals exposed to moderate childhood stress.
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spelling pubmed-48232032016-04-14 Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors Mandelli, Laura Toscano, Elena Porcelli, Stefano Fabbri, Chiara Serretti, Alessandro Psychiatry Investig Brief Report In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to stressful life events (SLEs). Eight polymorphisms (SNPs) were tested in 94 Schizophreniainpatients and 176 healthy controls. Schizophrenia patients were also evaluated for SLEs in different life periods. None of the SNPs showed association with schizophrenia. Nevertheless, when crossing genetic variants with childhood SLEs, we could observe trends of interaction with age of onset. Though several limitations, our results support a protective role of ST8SIA2 in individuals exposed to moderate childhood stress. Korean Neuropsychiatric Association 2016-03 2016-03-23 /pmc/articles/PMC4823203/ /pubmed/27081388 http://dx.doi.org/10.4306/pi.2016.13.2.247 Text en Copyright © 2016 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Mandelli, Laura
Toscano, Elena
Porcelli, Stefano
Fabbri, Chiara
Serretti, Alessandro
Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
title Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
title_full Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
title_fullStr Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
title_full_unstemmed Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
title_short Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
title_sort age of onset in schizophrenia spectrum disorders: complex interactions between genetic and environmental factors
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823203/
https://www.ncbi.nlm.nih.gov/pubmed/27081388
http://dx.doi.org/10.4306/pi.2016.13.2.247
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