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Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to stressful life events (SLEs). Eight polymorphisms (SNPs) were tested in 94 Schizophreniainpatients and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neuropsychiatric Association
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823203/ https://www.ncbi.nlm.nih.gov/pubmed/27081388 http://dx.doi.org/10.4306/pi.2016.13.2.247 |
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author | Mandelli, Laura Toscano, Elena Porcelli, Stefano Fabbri, Chiara Serretti, Alessandro |
author_facet | Mandelli, Laura Toscano, Elena Porcelli, Stefano Fabbri, Chiara Serretti, Alessandro |
author_sort | Mandelli, Laura |
collection | PubMed |
description | In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to stressful life events (SLEs). Eight polymorphisms (SNPs) were tested in 94 Schizophreniainpatients and 176 healthy controls. Schizophrenia patients were also evaluated for SLEs in different life periods. None of the SNPs showed association with schizophrenia. Nevertheless, when crossing genetic variants with childhood SLEs, we could observe trends of interaction with age of onset. Though several limitations, our results support a protective role of ST8SIA2 in individuals exposed to moderate childhood stress. |
format | Online Article Text |
id | pubmed-4823203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Neuropsychiatric Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-48232032016-04-14 Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors Mandelli, Laura Toscano, Elena Porcelli, Stefano Fabbri, Chiara Serretti, Alessandro Psychiatry Investig Brief Report In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to stressful life events (SLEs). Eight polymorphisms (SNPs) were tested in 94 Schizophreniainpatients and 176 healthy controls. Schizophrenia patients were also evaluated for SLEs in different life periods. None of the SNPs showed association with schizophrenia. Nevertheless, when crossing genetic variants with childhood SLEs, we could observe trends of interaction with age of onset. Though several limitations, our results support a protective role of ST8SIA2 in individuals exposed to moderate childhood stress. Korean Neuropsychiatric Association 2016-03 2016-03-23 /pmc/articles/PMC4823203/ /pubmed/27081388 http://dx.doi.org/10.4306/pi.2016.13.2.247 Text en Copyright © 2016 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Mandelli, Laura Toscano, Elena Porcelli, Stefano Fabbri, Chiara Serretti, Alessandro Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors |
title | Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors |
title_full | Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors |
title_fullStr | Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors |
title_full_unstemmed | Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors |
title_short | Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors |
title_sort | age of onset in schizophrenia spectrum disorders: complex interactions between genetic and environmental factors |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823203/ https://www.ncbi.nlm.nih.gov/pubmed/27081388 http://dx.doi.org/10.4306/pi.2016.13.2.247 |
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