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Energy metabolic dysfunction as a carcinogenic factor in cancer cells

Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed the mutual relationships among environmental pollution factors, energy metabolic dysfunctio...

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Detalles Bibliográficos
Autores principales: Sun, Yongyan, Shi, Zhenhua, Lian, Huiyong, Cai, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823226/
https://www.ncbi.nlm.nih.gov/pubmed/27053249
http://dx.doi.org/10.1186/s40169-016-0094-5
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author Sun, Yongyan
Shi, Zhenhua
Lian, Huiyong
Cai, Peng
author_facet Sun, Yongyan
Shi, Zhenhua
Lian, Huiyong
Cai, Peng
author_sort Sun, Yongyan
collection PubMed
description Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed the mutual relationships among environmental pollution factors, energy metabolic dysfunction, and various cancers. We found that most environmental pollution factors could induce cancers mainly by disturbing the energy metabolism. By triggering microenvironment alteration, energy metabolic dysfunction can be treated as a factor in carcinogenesis. Thus, we put forward that energy metabolism might be as a key point for studying carcinogenesis and tumor development to propose new methods for cancer prevention and therapy.
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spelling pubmed-48232262016-04-20 Energy metabolic dysfunction as a carcinogenic factor in cancer cells Sun, Yongyan Shi, Zhenhua Lian, Huiyong Cai, Peng Clin Transl Med Review Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed the mutual relationships among environmental pollution factors, energy metabolic dysfunction, and various cancers. We found that most environmental pollution factors could induce cancers mainly by disturbing the energy metabolism. By triggering microenvironment alteration, energy metabolic dysfunction can be treated as a factor in carcinogenesis. Thus, we put forward that energy metabolism might be as a key point for studying carcinogenesis and tumor development to propose new methods for cancer prevention and therapy. Springer Berlin Heidelberg 2016-04-06 /pmc/articles/PMC4823226/ /pubmed/27053249 http://dx.doi.org/10.1186/s40169-016-0094-5 Text en © Sun et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Sun, Yongyan
Shi, Zhenhua
Lian, Huiyong
Cai, Peng
Energy metabolic dysfunction as a carcinogenic factor in cancer cells
title Energy metabolic dysfunction as a carcinogenic factor in cancer cells
title_full Energy metabolic dysfunction as a carcinogenic factor in cancer cells
title_fullStr Energy metabolic dysfunction as a carcinogenic factor in cancer cells
title_full_unstemmed Energy metabolic dysfunction as a carcinogenic factor in cancer cells
title_short Energy metabolic dysfunction as a carcinogenic factor in cancer cells
title_sort energy metabolic dysfunction as a carcinogenic factor in cancer cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823226/
https://www.ncbi.nlm.nih.gov/pubmed/27053249
http://dx.doi.org/10.1186/s40169-016-0094-5
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