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Energy metabolic dysfunction as a carcinogenic factor in cancer cells
Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed the mutual relationships among environmental pollution factors, energy metabolic dysfunctio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823226/ https://www.ncbi.nlm.nih.gov/pubmed/27053249 http://dx.doi.org/10.1186/s40169-016-0094-5 |
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author | Sun, Yongyan Shi, Zhenhua Lian, Huiyong Cai, Peng |
author_facet | Sun, Yongyan Shi, Zhenhua Lian, Huiyong Cai, Peng |
author_sort | Sun, Yongyan |
collection | PubMed |
description | Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed the mutual relationships among environmental pollution factors, energy metabolic dysfunction, and various cancers. We found that most environmental pollution factors could induce cancers mainly by disturbing the energy metabolism. By triggering microenvironment alteration, energy metabolic dysfunction can be treated as a factor in carcinogenesis. Thus, we put forward that energy metabolism might be as a key point for studying carcinogenesis and tumor development to propose new methods for cancer prevention and therapy. |
format | Online Article Text |
id | pubmed-4823226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-48232262016-04-20 Energy metabolic dysfunction as a carcinogenic factor in cancer cells Sun, Yongyan Shi, Zhenhua Lian, Huiyong Cai, Peng Clin Transl Med Review Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed the mutual relationships among environmental pollution factors, energy metabolic dysfunction, and various cancers. We found that most environmental pollution factors could induce cancers mainly by disturbing the energy metabolism. By triggering microenvironment alteration, energy metabolic dysfunction can be treated as a factor in carcinogenesis. Thus, we put forward that energy metabolism might be as a key point for studying carcinogenesis and tumor development to propose new methods for cancer prevention and therapy. Springer Berlin Heidelberg 2016-04-06 /pmc/articles/PMC4823226/ /pubmed/27053249 http://dx.doi.org/10.1186/s40169-016-0094-5 Text en © Sun et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Sun, Yongyan Shi, Zhenhua Lian, Huiyong Cai, Peng Energy metabolic dysfunction as a carcinogenic factor in cancer cells |
title | Energy metabolic dysfunction as a carcinogenic factor in cancer cells |
title_full | Energy metabolic dysfunction as a carcinogenic factor in cancer cells |
title_fullStr | Energy metabolic dysfunction as a carcinogenic factor in cancer cells |
title_full_unstemmed | Energy metabolic dysfunction as a carcinogenic factor in cancer cells |
title_short | Energy metabolic dysfunction as a carcinogenic factor in cancer cells |
title_sort | energy metabolic dysfunction as a carcinogenic factor in cancer cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823226/ https://www.ncbi.nlm.nih.gov/pubmed/27053249 http://dx.doi.org/10.1186/s40169-016-0094-5 |
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