Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis

Defects in energy metabolism are potential pathogenic mechanisms in amyotrophic lateral sclerosis (ALS), a rapidly fatal disease with no cure. The mechanisms through which this occurs remain elusive and their understanding may prove therapeutically useful. We used metabolomics and stable isotope tra...

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Detalles Bibliográficos
Autores principales: Valbuena, Gabriel N., Rizzardini, Milena, Cimini, Sara, Siskos, Alexandros P., Bendotti, Caterina, Cantoni, Lavinia, Keun, Hector C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823370/
https://www.ncbi.nlm.nih.gov/pubmed/25963727
http://dx.doi.org/10.1007/s12035-015-9165-7

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