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A mathematical model of the dynamics of prion aggregates with chaperone-mediated fragmentation
Prions are proteins most commonly associated with fatal neurodegenerative diseases in mammals but are also responsible for a number of harmless heritable phenotypes in yeast. These states arise when a misfolded form of a protein appears and, rather than be removed by cellular quality control mechani...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823377/ https://www.ncbi.nlm.nih.gov/pubmed/26297259 http://dx.doi.org/10.1007/s00285-015-0921-0 |