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Dendritic Cells and Their Multiple Roles during Malaria Infection
Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses, efficiently presenting antigens to T cells. This ability relies on the presence of numerous surface and intracellular receptors capable of sensing microbial components as well as inflammation and on a very effi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823477/ https://www.ncbi.nlm.nih.gov/pubmed/27110574 http://dx.doi.org/10.1155/2016/2926436 |
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author | Amorim, Kelly N. S. Chagas, Daniele C. G. Sulczewski, Fernando B. Boscardin, Silvia B. |
author_facet | Amorim, Kelly N. S. Chagas, Daniele C. G. Sulczewski, Fernando B. Boscardin, Silvia B. |
author_sort | Amorim, Kelly N. S. |
collection | PubMed |
description | Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses, efficiently presenting antigens to T cells. This ability relies on the presence of numerous surface and intracellular receptors capable of sensing microbial components as well as inflammation and on a very efficient machinery for antigen presentation. In this way, DCs sense the presence of a myriad of pathogens, including Plasmodium spp., the causative agent of malaria. Despite many efforts to control this infection, malaria is still responsible for high rates of morbidity and mortality. Different groups have shown that DCs act during Plasmodium infection, and data suggest that the phenotypically distinct DCs subsets are key factors in the regulation of immunity during infection. In this review, we will discuss the importance of DCs for the induction of immunity against the different stages of Plasmodium, the outcomes of DCs activation, and also what is currently known about Plasmodium components that trigger such activation. |
format | Online Article Text |
id | pubmed-4823477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48234772016-04-24 Dendritic Cells and Their Multiple Roles during Malaria Infection Amorim, Kelly N. S. Chagas, Daniele C. G. Sulczewski, Fernando B. Boscardin, Silvia B. J Immunol Res Review Article Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses, efficiently presenting antigens to T cells. This ability relies on the presence of numerous surface and intracellular receptors capable of sensing microbial components as well as inflammation and on a very efficient machinery for antigen presentation. In this way, DCs sense the presence of a myriad of pathogens, including Plasmodium spp., the causative agent of malaria. Despite many efforts to control this infection, malaria is still responsible for high rates of morbidity and mortality. Different groups have shown that DCs act during Plasmodium infection, and data suggest that the phenotypically distinct DCs subsets are key factors in the regulation of immunity during infection. In this review, we will discuss the importance of DCs for the induction of immunity against the different stages of Plasmodium, the outcomes of DCs activation, and also what is currently known about Plasmodium components that trigger such activation. Hindawi Publishing Corporation 2016 2016-03-24 /pmc/articles/PMC4823477/ /pubmed/27110574 http://dx.doi.org/10.1155/2016/2926436 Text en Copyright © 2016 Kelly N. S. Amorim et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Amorim, Kelly N. S. Chagas, Daniele C. G. Sulczewski, Fernando B. Boscardin, Silvia B. Dendritic Cells and Their Multiple Roles during Malaria Infection |
title | Dendritic Cells and Their Multiple Roles during Malaria Infection |
title_full | Dendritic Cells and Their Multiple Roles during Malaria Infection |
title_fullStr | Dendritic Cells and Their Multiple Roles during Malaria Infection |
title_full_unstemmed | Dendritic Cells and Their Multiple Roles during Malaria Infection |
title_short | Dendritic Cells and Their Multiple Roles during Malaria Infection |
title_sort | dendritic cells and their multiple roles during malaria infection |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823477/ https://www.ncbi.nlm.nih.gov/pubmed/27110574 http://dx.doi.org/10.1155/2016/2926436 |
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