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Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling

It is well recognized that regulating the hair follicle cycle in association with Wnt signaling is one of the most interesting targets for promoting hair regrowth. In this study, we examined whether selected herbal medicines processed by decoction and fermentation promote hair growth by upregulating...

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Autores principales: Jang, Su Kil, Kim, Seung Tae, Lee, Do Ik, Park, Jun Sub, Jo, Bo Ram, Park, Jung Youl, Heo, Jong, Joo, Seong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823488/
https://www.ncbi.nlm.nih.gov/pubmed/27110266
http://dx.doi.org/10.1155/2016/4541580
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author Jang, Su Kil
Kim, Seung Tae
Lee, Do Ik
Park, Jun Sub
Jo, Bo Ram
Park, Jung Youl
Heo, Jong
Joo, Seong Soo
author_facet Jang, Su Kil
Kim, Seung Tae
Lee, Do Ik
Park, Jun Sub
Jo, Bo Ram
Park, Jung Youl
Heo, Jong
Joo, Seong Soo
author_sort Jang, Su Kil
collection PubMed
description It is well recognized that regulating the hair follicle cycle in association with Wnt signaling is one of the most interesting targets for promoting hair regrowth. In this study, we examined whether selected herbal medicines processed by decoction and fermentation promote hair growth by upregulating the number and size of hair follicles and Wnt signaling, including activation of β-catenin and Akt in telogen-synchronized C57BL/6N mice. The results revealed that the fermented extract after decoction (FDE) more effectively promoted hair growth than that of a nonfermented extract (DE). Notably, FDE effectively enhanced formation of hair follicles with clearer differentiation between the inner and outer root sheath, which is observed during the anagen phase. Mechanistic evidence was found for increased β-catenin and Akt phosphorylation levels in dorsal skin tissue along with elevated expression of hair regrowth-related genes, such as Wnt3/10a/10b, Lef1, and fibroblast growth factor 7. In conclusion, our findings suggest that FDE plays an important role in regulating the hair cycle by increasing expression of hair regrowth-related genes and activating downstream Wnt signaling targets.
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spelling pubmed-48234882016-04-24 Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling Jang, Su Kil Kim, Seung Tae Lee, Do Ik Park, Jun Sub Jo, Bo Ram Park, Jung Youl Heo, Jong Joo, Seong Soo Evid Based Complement Alternat Med Research Article It is well recognized that regulating the hair follicle cycle in association with Wnt signaling is one of the most interesting targets for promoting hair regrowth. In this study, we examined whether selected herbal medicines processed by decoction and fermentation promote hair growth by upregulating the number and size of hair follicles and Wnt signaling, including activation of β-catenin and Akt in telogen-synchronized C57BL/6N mice. The results revealed that the fermented extract after decoction (FDE) more effectively promoted hair growth than that of a nonfermented extract (DE). Notably, FDE effectively enhanced formation of hair follicles with clearer differentiation between the inner and outer root sheath, which is observed during the anagen phase. Mechanistic evidence was found for increased β-catenin and Akt phosphorylation levels in dorsal skin tissue along with elevated expression of hair regrowth-related genes, such as Wnt3/10a/10b, Lef1, and fibroblast growth factor 7. In conclusion, our findings suggest that FDE plays an important role in regulating the hair cycle by increasing expression of hair regrowth-related genes and activating downstream Wnt signaling targets. Hindawi Publishing Corporation 2016 2016-03-24 /pmc/articles/PMC4823488/ /pubmed/27110266 http://dx.doi.org/10.1155/2016/4541580 Text en Copyright © 2016 Su Kil Jang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jang, Su Kil
Kim, Seung Tae
Lee, Do Ik
Park, Jun Sub
Jo, Bo Ram
Park, Jung Youl
Heo, Jong
Joo, Seong Soo
Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling
title Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling
title_full Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling
title_fullStr Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling
title_full_unstemmed Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling
title_short Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnts Signaling
title_sort decoction and fermentation of selected medicinal herbs promote hair regrowth by inducing hair follicle growth in conjunction with wnts signaling
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823488/
https://www.ncbi.nlm.nih.gov/pubmed/27110266
http://dx.doi.org/10.1155/2016/4541580
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