Growth hormone (GH)‐transgenic insulin‐like growth factor 1 (IGF1)‐deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth

Growth hormone (GH)‐transgenic mice with permanently elevated systemic levels of GH and insulin‐like growth factor 1 (IGF1) reproducibly develop renal and glomerular hypertrophy and subsequent progressive glomerulosclerosis, finally leading to terminal renal failure. To dissociate IGF1‐dependent and...

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Detalles Bibliográficos
Autores principales: Blutke, Andreas, Schneider, Marlon R., Wolf, Eckhard, Wanke, Rüdiger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823598/
https://www.ncbi.nlm.nih.gov/pubmed/26997624
http://dx.doi.org/10.14814/phy2.12709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823598/
https://www.ncbi.nlm.nih.gov/pubmed/26997624
http://dx.doi.org/10.14814/phy2.12709

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