Cargando…

Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network

Phosphopantetheinyl transferases (PPTases) play essential roles in both primary metabolisms and secondary metabolisms via post-translational modification of acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs). In this study, an industrial FK506 producing strain Streptomyces tsukubaensi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yue-Yue, Zhang, Xiao-Sheng, Luo, Hong-Dou, Ren, Ni-Ni, Jiang, Xin-Hang, Jiang, Hui, Li, Yong-Quan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823652/ https://www.ncbi.nlm.nih.gov/pubmed/27052100 http://dx.doi.org/10.1038/srep24255

Ejemplares similares

Characterization and Evolutionary Implications of the Triad Asp-Xxx-Glu in Group II Phosphopantetheinyl Transferases
por: Wang, Yue-Yue, et al.
Publicado: (2014)

Enhanced Rishirilide Biosynthesis by a Rare In-Cluster Phosphopantetheinyl Transferase in Streptomyces xanthophaeus
por: Zhang, Songya, et al.
Publicado: (2022)

Distribution and functional analysis of the phosphopantetheinyl transferase superfamily in Actinomycetales microorganisms
por: Kim, Jeong Ho, et al.
Publicado: (2018)

Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds
por: Carivenc, Coralie, et al.
Publicado: (2021)

Two Functionally Distinctive Phosphopantetheinyl Transferases from Amoeba Dictyostelium discoideum
por: Nair, Divya R., et al.
Publicado: (2011)

In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas
por: Ottavi, Samantha, et al.
Publicado: (2022)

Labeling surface proteins with high specificity: Intrinsic limitations of phosphopantetheinyl transferase systems
por: Stüber, Jakob C., et al.
Publicado: (2019)

Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis
por: Pandey, Shilpika, et al.
Publicado: (2021)

Structure, Biochemistry, and Inhibition of Essential 4′-Phosphopantetheinyl Transferases from Two Species of Mycobacteria
por: Vickery, Christopher R., et al.
Publicado: (2014)

Cyanobacterial Sfp-type phosphopantetheinyl transferases functionalize carrier proteins of diverse biosynthetic pathways
por: Yang, Guang, et al.
Publicado: (2017)

Speed dating for enzymes! Finding the perfect phosphopantetheinyl transferase partner for your polyketide synthase
por: Pedersen, Tobias Bruun, et al.
Publicado: (2022)

Characterisation of the Candida albicans Phosphopantetheinyl Transferase Ppt2 as a Potential Antifungal Drug Target
por: Dobb, Katharine S., et al.
Publicado: (2015)

Phosphopantetheinyl transferase ClbA contributes to the virulence of avian pathogenic Escherichia coli in meningitis infection of mice
por: Meng, Xia, et al.
Publicado: (2022)

A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in Streptomyces ambofaciens ATCC23877
por: Bunet, Robert, et al.
Publicado: (2014)

The Sfp-Type 4′-Phosphopantetheinyl Transferase Ppt1 of Fusarium fujikuroi Controls Development, Secondary Metabolism and Pathogenicity
por: Wiemann, Philipp, et al.
Publicado: (2012)

Insights from the docking and molecular dynamics simulation of the Phosphopantetheinyl transferase (PptT) structural model from Mycobacterium tuberculosis
por: Rohini, Karunakaran, et al.
Publicado: (2013)

Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase
por: Tobias, Nicholas J., et al.
Publicado: (2016)

4′-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo
por: Leblanc, Cécile, et al.
Publicado: (2012)

Phosphopantetheinyl transferase (Ppt)-mediated biosynthesis of lysine, but not siderophores or DHN melanin, is required for virulence of Zymoseptoria tritici on wheat
por: Derbyshire, Mark C., et al.
Publicado: (2018)

The Impacts of Sortase A and the 4′-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis
por: Morales-Aparicio, Joyce C., et al.
Publicado: (2020)

Dinoflagellate Phosphopantetheinyl Transferase (PPTase) and Thiolation Domain Interactions Characterized Using a Modified Indigoidine Synthesizing Reporter
por: Williams, Ernest, et al.
Publicado: (2022)

Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis
por: Jung, James, et al.
Publicado: (2016)

A Novel Rapid Fungal Promoter Analysis System Using the Phosphopantetheinyl Transferase Gene, npgA, in Aspergillus nidulans
por: Song, Ha-Yeon, et al.
Publicado: (2018)

Author Correction: Phosphopantetheinyl transferase (Ppt)-mediated biosynthesis of lysine, but not siderophores or DHN melanin, is required for virulence of Zymoseptoria tritici on wheat
por: Derbyshire, Mark C., et al.
Publicado: (2019)

Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT
por: Brown, Alistair S., et al.
Publicado: (2021)

An in-cluster Sfp-type phosphopantetheinyl transferase instead of the holo-ACP synthase activates the granaticin biosynthesis under natural physiological conditions
por: Deng, Ming-Rong, et al.
Publicado: (2022)

A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity
por: Johns, Anna, et al.
Publicado: (2017)

Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli
por: Baron, Szilvia, et al.
Publicado: (2018)

Down regulation of the expression of mitochondrial phosphopantetheinyl-proteins in pantothenate kinase-associated neurodegeneration: pathophysiological consequences and therapeutic perspectives
por: Álvarez-Córdoba, Mónica, et al.
Publicado: (2021)

The Onset of Tacrolimus Biosynthesis in Streptomyces tsukubaensis Is Dependent on the Intracellular Redox Status
por: Pires, Sílvia D. S., et al.
Publicado: (2020)

Optimization of the precursor supply for an enhanced FK506 production in Streptomyces tsukubaensis
por: Schulz, Susann, et al.
Publicado: (2022)

Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis
por: Wu, Qing-Bin, et al.
Publicado: (2021)

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis
por: Goranovič, Dušan, et al.
Publicado: (2012)

Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches
por: Ordóñez-Robles, María, et al.
Publicado: (2018)

Draft Genome Sequence of the Tacrolimus-Producing Bacterium Streptomyces tsukubaensis F601
por: Zong, Gongli, et al.
Publicado: (2017)

Optimization of FK-506 production in Streptomyces tsukubaensis by modulation of Crp-mediated regulation
por: Schulz, Susann, et al.
Publicado: (2023)

Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement
por: Huang, Di, et al.
Publicado: (2013)

4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a Potent Inhibitor of Bacterial Phosphopantetheinyl Transferase That Attenuates Secondary Metabolism and Thwarts Bacterial Growth
por: Foley, Timothy L., et al.
Publicado: (2014)

Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis
por: Blažič, Marko, et al.
Publicado: (2015)

Evaluation of carbon:nitrogen ratio in semi-defined culture medium to tacrolimus biosynthesis by Streptomyces tsukubaensis and the effect on bacterial growth
por: Moreira, Jean Vinícius, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jenkid3tvbkroj3jpbs9jlk67m