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Procaspase-9 induces its cleavage by transnitrosylating XIAP via the Thioredoxin system during cerebral ischemia-reperfusion in rats

Transnitrosylation is an important mechanism by which nitric oxide (NO) modulates cell signaling pathways. For instance, SNO-caspase-3 can transnitrosylate the X-linked inhibitor of apoptosis (XIAP) to enhance apoptosis. XIAP is a potent antagonist of caspase apoptotic activity. Decrease in XIAP act...

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Detalles Bibliográficos
Autores principales:	Zhang, Dengyue, Zhao, Ningjun, Ma, Bin, Wang, Yan, Zhang, Gongliang, Yan, Xianliang, Hu, Shuqun, Xu, Tie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823698/ https://www.ncbi.nlm.nih.gov/pubmed/27052476 http://dx.doi.org/10.1038/srep24203

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