Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin

Allosteric partial inhibition of soluble, monomeric proteases can offer major regulatory advantages, but remains a concept on paper to date; although it has been routinely documented for receptors and oligomeric proteins. Thrombin, a key protease of the coagulation cascade, displays significant conf...

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Detalles Bibliográficos
Autores principales: Verespy III, Stephen, Mehta, Akul Y., Afosah, Daniel, Al-Horani, Rami A., Desai, Umesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823711/
https://www.ncbi.nlm.nih.gov/pubmed/27053426
http://dx.doi.org/10.1038/srep24043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823711/
https://www.ncbi.nlm.nih.gov/pubmed/27053426
http://dx.doi.org/10.1038/srep24043

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