Cargando…

A novel therapeutic strategy of lipidated promiscuous peptide against Mycobacterium tuberculosis by eliciting Th1 and Th17 immunity of host

Regardless of the fact that potent drug-regimen is currently available, tuberculosis continues to kill 1.5 million people annually. Tuberculosis patients are not only inflicted by the trauma of disease but they also suffer from the harmful side-effects, immune suppression and drug resistance instiga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rai, Pradeep K, Chodisetti, Sathi Babu, Nadeem, Sajid, Maurya, Sudeep K, Gowthaman, Uthaman, Zeng, Weiguang, Janmeja, Ashok K, Jackson, David C, Agrewala, Javed N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823727/ https://www.ncbi.nlm.nih.gov/pubmed/27052185 http://dx.doi.org/10.1038/srep23917

Ejemplares similares

A lipidated bi-epitope vaccine comprising of MHC-I and MHC-II binder peptides elicits protective CD4 T cell and CD8 T cell immunity against Mycobacterium tuberculosis
por: Rai, Pradeep K., et al.
Publicado: (2018)

A lipidated peptide of Mycobacterium tuberculosis resuscitates the protective efficacy of BCG vaccine by evoking memory T cell immunity
por: Rai, Pradeep K., et al.
Publicado: (2017)

Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis
por: Babu Chodisetti, Sathi, et al.
Publicado: (2012)

Lipidated promiscuous peptide augments the expression of MHC-II molecules on dendritic cells and activates T cells
por: Gowthaman, Uthaman, et al.
Publicado: (2013)

Gut Dysbiosis Thwarts the Efficacy of Vaccine Against Mycobacterium tuberculosis
por: Nadeem, Sajid, et al.
Publicado: (2020)

CD40 Signaling Synergizes with TLR-2 in the BCR Independent Activation of Resting B Cells
por: Jain, Shweta, et al.
Publicado: (2011)

Combinatorial Signaling through TLR-2 and CD86 Augments Activation and Differentiation of Resting B Cells
por: Jain, Shweta, et al.
Publicado: (2013)

Correction: Combinatorial Signaling through TLR-2 and CD86 Augments Activation and Differentiation of Resting B Cells
por: Jain, Shweta, et al.
Publicado: (2014)

Caerulomycin A inhibits Th2 cell activity: a possible role in the management of asthma
por: Kujur, Weshely, et al.
Publicado: (2015)

A multiple T cell epitope comprising DNA vaccine boosts the protective efficacy of Bacillus Calmette–Guérin (BCG) against Mycobacterium tuberculosis
por: Maurya, Sudeep Kumar, et al.
Publicado: (2020)

Manipulation of Costimulatory Molecules by Intracellular Pathogens: Veni, Vidi, Vici!!
por: Khan, Nargis, et al.
Publicado: (2012)

A genomic analysis of Mycobacterium immunogenum strain CD11_6 and its potential role in the activation of T cells against Mycobacterium tuberculosis
por: Kaur, Gurpreet, et al.
Publicado: (2019)

Co-Administration of IL-1+IL-6+TNF-α with Mycobacterium tuberculosis Infected Macrophages Vaccine Induces Better Protective T Cell Memory than BCG
por: Singh, Vijender, et al.
Publicado: (2011)

Regulatory role of pro-Th1 and pro-Th2 cytokines in modulating the activity of Th1 and Th2 cells when B cell and macrophages are used as antigen presenting cells
por: Singh, Vinod, et al.
Publicado: (2006)

Cumulative Signaling Through NOD-2 and TLR-4 Eliminates the Mycobacterium Tuberculosis Concealed Inside the Mesenchymal Stem Cells
por: Aqdas, Mohammad, et al.
Publicado: (2021)

Targeting dendritic cells with TLR-2 ligand–coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce antituberculosis immunity
por: Kumar Das, Deepjyoti, et al.
Publicado: (2022)

Diametric Role of the Latency-Associated Protein Acr1 of Mycobacterium tuberculosis in Modulating the Functionality of Pre- and Post-maturational Stages of Dendritic Cells
por: Amir, Mohammed, et al.
Publicado: (2017)

Antibody response against PhoP efficiently discriminates among healthy individuals, tuberculosis patients and their contacts
por: Vidyarthi, Aurobind, et al.
Publicado: (2017)

Leishmania-Specific Promiscuous Membrane Protein Tubulin Folding Cofactor D Divulges Th(1)/Th(2) Polarization in the Host via ERK-1/2 and p38 MAPK Signaling Cascade
por: Jamal, Fauzia, et al.
Publicado: (2020)

Low prevalence of anti‐xenobiotic antibodies among the occupationally exposed individuals is associated with a high risk of cancer
por: Sajid, Mohammad, et al.
Publicado: (2018)

Potential Role of Gut Microbiota in Induction and Regulation of Innate Immune Memory
por: Negi, Shikha, et al.
Publicado: (2019)

Molecular mimicry: Good artists copy, great artists steal
por: Gowthaman, Uthaman, et al.
Publicado: (2013)

Corrigendum: Leishmania-Specific Promiscuous Membrane Protein Tubulin Folding Cofactor D Divulges Th(1)/Th(2) Polarization in the Host via ERK-1/2 and p38 MAPK Signaling Cascade
por: Jamal, Fauzia, et al.
Publicado: (2020)

Innate Immunity Holding the Flanks until Reinforced by Adaptive Immunity against Mycobacterium tuberculosis Infection
por: Khan, Nargis, et al.
Publicado: (2016)

Alteration in the Gut Microbiota Provokes Susceptibility to Tuberculosis
por: Khan, Nargis, et al.
Publicado: (2016)

Molecular docking studies of dithionitrobenzoic acid and its related compounds to protein disulfide isomerase: computational screening of inhibitors to HIV-1 entry
por: Gowthaman, Uthaman, et al.
Publicado: (2008)

Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)
por: Mencher, Simon K, et al.
Publicado: (2005)

Gut Microbiota Regulates Mincle Mediated Activation of Lung Dendritic Cells to Protect Against Mycobacterium tuberculosis
por: Negi, Shikha, et al.
Publicado: (2019)

Mycobacterium smegmatis Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With Mycobacterium avium
por: Kannan, Nisha, et al.
Publicado: (2020)

TLR7 Negatively Regulates B10 Cells Predominantly in an IFNγ Signaling Dependent Manner
por: Chodisetti, Sathi Babu, et al.
Publicado: (2020)

Novel Th17 Lymphocyte Populations, Th17.1 and PD1+Th17, are Increased in Takayasu Arteritis, and Both Th17 and Th17.1 Sub-Populations Associate with Active Disease
por: Singh, Kritika, et al.
Publicado: (2022)

Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions
por: Arora, Simran Kaur, et al.
Publicado: (2020)

Prediabetes is associated with the modulation of antigen-specific Th1/Tc1 and Th17/Tc17 responses in latent Mycobacterium tuberculosis infection
por: Kumar, Nathella Pavan, et al.
Publicado: (2017)

Stimulation through CD40 and TLR-4 Is an Effective Host Directed Therapy against Mycobacterium tuberculosis
por: Khan, Nargis, et al.
Publicado: (2016)

Signaling through NOD-2 and TLR-4 Bolsters the T cell Priming Capability of Dendritic cells by Inducing Autophagy
por: Khan, Nargis, et al.
Publicado: (2016)

Curdlan Limits Mycobacterium tuberculosis Survival Through STAT-1 Regulated Nitric Oxide Production
por: Negi, Shikha, et al.
Publicado: (2019)

Monocytes Elicit a Neutrophil-Independent Th1/Th17 Response Upon Immunization With a Mincle-Dependent Glycolipid Adjuvant
por: Desel, Christiane, et al.
Publicado: (2022)

Infergen Stimulated Macrophages Restrict Mycobacterium tuberculosis Growth by Autophagy and Release of Nitric Oxide
por: Pahari, Susanta, et al.
Publicado: (2016)

Corrigendum: Curdlan Limits Mycobacterium tuberculosis Survival Through STAT-1 Regulated Nitric Oxide Production
por: Negi, Shikha, et al.
Publicado: (2022)

Mycobacterium tuberculosis Complex in Remains of 18th–19th Century Slaves, Brazil
por: Jaeger, Lauren H., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vsgd1b4ia17ljcl11c1h315lla